Gene interactions and pathways from curated databases and text-mining

◀ Back to AKT1

AKT1 — SPRY2

Text-mined interactions from Literome

Lito et al., J Biol Chem 2009 : In agreement with these findings, overexpression of Spry2 in the parental non transformed fibroblasts led to increased Akt activation and to the stabilization of HDM2
Lee et al., Hepatology 2010 (Carcinoma, Hepatocellular...) : In HCC cell lines, Spry2 overexpression inhibits c-Met induced cell proliferation as well as ERK and AKT activation, whereas loss of Spry2 potentiates c-Met signaling
Patel et al., J Clin Invest 2013 (Cell Transformation, Neoplastic...) : Here, we show that SPRY2 deficiency alone triggers activation of AKT and ERK, but this is insufficient to drive tumorigenesis
Zhu et al., Dev Biol 2013 : The pattern of SPRY2 expression, and thus of Akt activation and branch initiation, was controlled by mechanical signaling from endogenous cytoskeletal contractility