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MAPK3 — SPP1
Text-mined interactions from Literome
Xie et al., J Cell Physiol 2001
:
These results suggest that p42/44
MAPK is a critical component of the ROS-sensitive signaling pathways activated by ANG II in CMEC and
plays a key role in the regulation of
osteopontin gene expression
Vann et al., J Biol Chem 2002
(Glioma) :
However, both SPP and
dihydro-SPP markedly
stimulated ERK 1/2 in C6 cells, which express cell surface SPP receptors
Chang et al., Int J Biochem Cell Biol 2002
:
Using the JB6 cell model, we determined the
involvement of PKC isoforms,
mitogen activated protein kinase kinase ( MAPK kinase/MEK ) and MAPK in TPA induced
OPN expression using inhibitors specific to PKC isoforms and MEK and performing Northern blot analyses ... TPA induced steady-state
OPN mRNA expression in mouse JB6 cells
involves the activation of
MAPK mediated through PKC epsilon and/or PKC delta
Li et al., J Appl Physiol 2004
(Anoxia) :
In contrast, FGF-1 induced
OPN expression was
blocked by inhibitors of JNK or MEK1/2 but not of PI3K, p70S6K, or
p38MAPK
Rangaswami et al., J Biol Chem 2004
(MAP Kinase Signaling System...) :
Nuclear factor inducing kinase plays a crucial role in
osteopontin induced
MAPK/IkappaBalpha kinase dependent nuclear factor kappaB mediated promatrix metalloproteinase-9 activation
Jeon et al., Mol Cell Biochem 2009
(MAP Kinase Signaling System) :
Role of
MAPK in mechanical force induced up-regulation of type I collagen and
osteopontin in human gingival fibroblasts
Yang et al., J Thorac Cardiovasc Surg 2009
(Aortic Valve Stenosis...) :
Silencing Smad1 reduced Runx2 and osteopontin levels, whereas inhibition of
extracellular signal regulated kinase 1/2 reduced
osteopontin expression without an influence on Runx2 expression
Camalier et al., Cancer prevention research (Philadelphia, Pa.) 2010
(Cell Transformation, Neoplastic...) :
Supplementation of medium with phosphate increased anchorage independent transformation and proliferation of BALB/c mouse JB6 epidermal cells,
activation of N-ras,
ERK1/2 , and activator protein-1, and increased gene expression of Fra-1, COX-2, and
osteopontin in a dose dependent manner
Robertson et al., Molecular cancer 2010
(Prostatic Neoplasms) :
Regulation of
Erk1/2 activation by
osteopontin in PC3 human prostate cancer cells ... We propose this based on the observations that while
OPN activates c-Raf and
Erk1/2 ; it also acts to inhibit c-Raf and Erk1/2 activation through Akt pathway
Suzuki et al., Ann Neurol 2010
(Disease Models, Animal...) :
r-OPN enhanced an endogenous
MAPK inhibitor, MKP-1, and suppressed the phosphorylation of MAPKs, caldesmon, and heat shock protein 27 in the spastic cerebral arteries at 24 hours post-SAH
Atkins et al., Arch Biochem Biophys 1997
:
Thus, TPA stimulated transcription of the
OPN gene apparently occurs via a
PKC/MAPK dependent mechanism that is independent of that associated with differentiation and is not dependent on the maturational state of these cells
Kozawa et al., FEBS Lett 1997
:
SPP significantly
induced p42/p44
mitogen activated protein ( MAP ) kinase activity