Gene interactions and pathways from curated databases and text-mining

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MAPK3 — SPP1

Text-mined interactions from Literome

Xie et al., J Cell Physiol 2001 : These results suggest that p42/44 MAPK is a critical component of the ROS-sensitive signaling pathways activated by ANG II in CMEC and plays a key role in the regulation of osteopontin gene expression
Vann et al., J Biol Chem 2002 (Glioma) : However, both SPP and dihydro-SPP markedly stimulated ERK 1/2 in C6 cells, which express cell surface SPP receptors
Chang et al., Int J Biochem Cell Biol 2002 : Using the JB6 cell model, we determined the involvement of PKC isoforms, mitogen activated protein kinase kinase ( MAPK kinase/MEK ) and MAPK in TPA induced OPN expression using inhibitors specific to PKC isoforms and MEK and performing Northern blot analyses ... TPA induced steady-state OPN mRNA expression in mouse JB6 cells involves the activation of MAPK mediated through PKC epsilon and/or PKC delta
Li et al., J Appl Physiol 2004 (Anoxia) : In contrast, FGF-1 induced OPN expression was blocked by inhibitors of JNK or MEK1/2 but not of PI3K, p70S6K, or p38MAPK
Rangaswami et al., J Biol Chem 2004 (MAP Kinase Signaling System...) : Nuclear factor inducing kinase plays a crucial role in osteopontin induced MAPK/IkappaBalpha kinase dependent nuclear factor kappaB mediated promatrix metalloproteinase-9 activation
Jeon et al., Mol Cell Biochem 2009 (MAP Kinase Signaling System) : Role of MAPK in mechanical force induced up-regulation of type I collagen and osteopontin in human gingival fibroblasts
Yang et al., J Thorac Cardiovasc Surg 2009 (Aortic Valve Stenosis...) : Silencing Smad1 reduced Runx2 and osteopontin levels, whereas inhibition of extracellular signal regulated kinase 1/2 reduced osteopontin expression without an influence on Runx2 expression
Camalier et al., Cancer prevention research (Philadelphia, Pa.) 2010 (Cell Transformation, Neoplastic...) : Supplementation of medium with phosphate increased anchorage independent transformation and proliferation of BALB/c mouse JB6 epidermal cells, activation of N-ras, ERK1/2 , and activator protein-1, and increased gene expression of Fra-1, COX-2, and osteopontin in a dose dependent manner
Robertson et al., Molecular cancer 2010 (Prostatic Neoplasms) : Regulation of Erk1/2 activation by osteopontin in PC3 human prostate cancer cells ... We propose this based on the observations that while OPN activates c-Raf and Erk1/2 ; it also acts to inhibit c-Raf and Erk1/2 activation through Akt pathway
Suzuki et al., Ann Neurol 2010 (Disease Models, Animal...) : r-OPN enhanced an endogenous MAPK inhibitor, MKP-1, and suppressed the phosphorylation of MAPKs, caldesmon, and heat shock protein 27 in the spastic cerebral arteries at 24 hours post-SAH
Atkins et al., Arch Biochem Biophys 1997 : Thus, TPA stimulated transcription of the OPN gene apparently occurs via a PKC/MAPK dependent mechanism that is independent of that associated with differentiation and is not dependent on the maturational state of these cells
Kozawa et al., FEBS Lett 1997 : SPP significantly induced p42/p44 mitogen activated protein ( MAP ) kinase activity