◀ Back to AKT1

AKT1 — SPP1

Text-mined interactions from Literome

Das et al., J Biol Chem 2003 (Breast Neoplasms) : The OPN induced Akt phosphorylation was inhibited when cells were transfected with a dominant negative mutant of the p85 domain of PI 3-kinase ( Deltap85 ) and enhanced when cells were transfected with an activated form of PI 3-kinase ( p110CAAX ), indicating that PI 3'-kinase is involved in Akt phosphorylation ... OPN enhances the interaction between IkappaBalpha kinase (IKK) and phosphorylated Akt ... However, both pharmacological ( wortmannin and LY294002 ) and genetic ( Deltap85 ) inhibitors of PI 3'-kinase inhibited OPN induced Akt phosphorylation, IKK activity, and NFkappaB activation through phosphorylation and degradation of IkappaBalpha ... To our knowledge, this is first report that OPN induces NFkappaB activity and uPA secretion by activating PI 3'-kinase/Akt/IKK mediated signaling pathways and further demonstrates a functional molecular link between OPN induced PI 3'-kinase dependent Akt phosphorylation and NFkappaB mediated uPA secretion, and all of these ultimately control the motility of breast cancer cells
Das et al., IUBMB Life 2005 (Disease Progression...) : The OPN induced Akt phosphorylation was inhibited when cells were transfected with dominant negative mutant of p85 domain of PI 3'-kinase ( Deltap85 ) indicating that PI 3'-kinase is involved in Akt phosphorylation ... OPN enhances the interaction between IkappaBalpha kinase (IKK) and phosphorylated Akt
Zhang et al., Exp Oncol 2006 (Carcinoma, Hepatocellular...) : Osteopontin regulation by protein kinase B ( Akt ) in HepG2 cells
Song et al., Experimental biology and medicine (Maywood, N.J.) 2008 (Stomach Neoplasms) : Furthermore, PI3-K inhibitor LY294002 attenuated OPN mediated Akt activation
Dai et al., Oncogene 2009 : Osteopontin induces angiogenesis through activation of PI3K/AKT and ERK1/2 in endothelial cells
Robertson et al., Exp Cell Res 2010 (Prostatic Neoplasms) : Osteopontin induces beta-catenin signaling through activation of Akt in prostate cancer cells ... Our work demonstrates that OPN can activate Akt , an important step in cancer progression ... Both ILK and PI3K are integral proteins in the OPN/Akt pathway, as inhibition of either kinase leads to a loss of OPN mediated Akt activation ... Subsequent to OPN induced Akt activation, we observe inactivation of GSK-3beta, a regulator of beta-catenin
Robertson et al., Molecular cancer 2010 (Prostatic Neoplasms) : We have recently demonstrated the activation of Akt by OPN ... To investigate the role of the extracellular receptors in OPN signaling, we have examined the spatio-temporal regulation of CD44 and integrin avß3 receptor in OPN induced Akt activation in PC3 cells ... Here, our studies demonstrate that OPN can activate Akt either through the aVß3 integrin or the CD44 cell surface receptor