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AKT1 — SPHK1

Text-mined interactions from Literome

Monick et al., Am J Respir Cell Mol Biol 2004 (Respiratory Syncytial Virus Infections) : S1P activated Akt and ERK within minutes, and inhibition of sphingosine kinase blocked RSV induced ERK and Akt activation, leading to accelerated cell death after viral infection
Johnstone et al., Placenta 2005 : Inhibition of SPHK-1 also did not affect EGF stimulated phosphorylation of PI-3 kinase, Akt , ERK1/2 or p38 but inhibition of PI-3 kinase with a specific inhibitor LY294002 partly ( 40 % ) inhibited the EGF stimulated increase in SPHK-1 activity
Hart et al., Biol Chem 2005 (Breast Neoplasms) : Notably, activation of the PI3K downstream mediator PKB/Akt by GPCR ligands involves the activity of sphingosine kinase ( SPHK ) and is independent of EGFR signal transactivation ... Notably, activation of the PI3K downstream mediator PKB/Akt by GPCR ligands involves the activity of sphingosine kinase ( SPHK ) and is independent of EGFR signal transactivation
Radeff-Huang et al., J Biol Chem 2007 (Brain Neoplasms...) : Tumor necrosis factor-alpha stimulated cell proliferation is mediated through sphingosine kinase dependent Akt activation and cyclin D expression ... We conclude that SphK dependent Akt activation plays a significant role in TNF-alpha induced cyclin D expression and cell proliferation
Osawa et al., FASEB J 2011 : Loss of sphingosine kinase-1 (SphK1) diminished ASM mediated AKT phosphorylation, but exogenous S1P induced AKT activation in hepatocytes
Beckham et al., Oncogenesis 2013 : Acid ceramidase induces sphingosine kinase 1/S1P receptor 2-mediated activation of oncogenic Akt signaling