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IGF1 — SPAG8
Text-mined interactions from Literome
Tomlinson et al., Endocr Res 2000
(Obesity...) :
IGF-1 caused a dose dependant inhibition of
11beta-HSD1 activity in both subcutaneous and omental stromal cells
Stewart et al., Horm Res 2001
(Hypopituitarism...) :
These clinical data suggest that GH ( and/or IGF-I ) inhibits 11beta-HSD1 ( i.e. E to F conversion ) ( parallel in vitro studies suggest that
IGF-I and not GH
inhibits 11beta-HSD1 )
Patel et al., Development 2008
:
Finally, we found that the
HSD-1 mediated signal
activates insulin/IGF-I signaling in a cell non-autonomous fashion, suggesting a novel mechanism for how these two endocrine pathways intersect in directing development
Morita et al., Endocr J 2009
:
In the present study, we investigated the
effects of GH or
IGF-I on the activity of 11beta-
HSD1 in 3T3-L1 cell homogenates and its mRNA expression