Gene interactions and pathways from curated databases and text-mining

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IGF1 — SPAG8

Text-mined interactions from Literome

Tomlinson et al., Endocr Res 2000 (Obesity...) : IGF-1 caused a dose dependant inhibition of 11beta-HSD1 activity in both subcutaneous and omental stromal cells
Stewart et al., Horm Res 2001 (Hypopituitarism...) : These clinical data suggest that GH ( and/or IGF-I ) inhibits 11beta-HSD1 ( i.e. E to F conversion ) ( parallel in vitro studies suggest that IGF-I and not GH inhibits 11beta-HSD1 )
Patel et al., Development 2008 : Finally, we found that the HSD-1 mediated signal activates insulin/IGF-I signaling in a cell non-autonomous fashion, suggesting a novel mechanism for how these two endocrine pathways intersect in directing development
Morita et al., Endocr J 2009 : In the present study, we investigated the effects of GH or IGF-I on the activity of 11beta- HSD1 in 3T3-L1 cell homogenates and its mRNA expression