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SP3 — STAT3
Text-mined interactions from Literome
Loeffler et al., Int J Cancer 2005
(Glioblastoma) :
Interestingly, preincubation with STAT3 antibody prevented the binding of Sp1 and Sp3 to the -88/-50 element, indicating that
STAT3 is
involved in IL-6-driven
Sp1/Sp3 protein-DNA complex formation
Su et al., Am J Physiol Cell Physiol 2009
:
Cell confluency induced
Stat3 activation
regulates NHE3 expression by recruiting Sp1 and
Sp3 to the proximal NHE3 promoter region during epithelial dome formation ... Thus, during confluency, ligand independent
Stat3 activation
leads to its interaction with
Sp1/Sp3 , their recruitment to the SpA/B/C cluster in a Stat3 DNA binding domain dependent fashion, increased transcription, and expression of NHE3, to coordinate cell density mediated epithelial dome formation