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IGF2 — SP1
Text-mined interactions from Literome
Kang-Park et al., Biochem Biophys Res Commun 2001
(Carcinoma, Hepatocellular...) :
We have recently shown that HBx protein, one of the causative agents of hepatocellular carcinomas, regulates
Sp1 mediated transcription of
insulin-like growth factor II promoter 4 ( Lee et al. ( 1998 ) Oncogene 16, 2367-2380 ) ... These results demonstrate that PKC and p44/p42 MAPK cascades are the essential signaling pathways in
Sp1 mediated
IGF-II gene activation by HBx
Maor et al., J Endocrinol 2006
(Breast Neoplasms) :
In summary, our studies demonstrate that
IGF-IR gene transcription in breast cancer cells is
controlled by interactions between ERalpha and
Sp1
Yuen et al., Oncogene 2007
(Carcinoma, Renal Cell...) :
In Sp1-null Drosophila Schneider cells,
IGF1R promoter activity was
dependent on exogenous
Sp1 , and was suppressed by full-length VHL protein ( pVHL ) but only partially by truncated VHL lacking the Sp1 binding motif
Lee et al., Oncogene 1998
(Carcinoma, Hepatocellular) :
The human hepatitis B virus transactivator X gene product regulates
Sp1 mediated transcription of an
insulin-like growth factor II promoter 4 ... These results indicate that HBV-X functions as a positive regulator of transcription, and that
Sp1 is a direct
target for the transcriptional regulation of
IGF-II