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IGF1 — SP1

Text-mined interactions from Literome

Zhu et al., Mol Cell Endocrinol 2000 : Involvement of Sp1 in the transcriptional regulation of the rat insulin-like growth factor-1 gene ... Since potential Sp1 sites are found in footprinted regions within approximately 360 bp upstream and downstream from the major initiation sites in exon 1, we explored the involvement of Sp1 and Sp3 in regulation of IGF-1 expression ... Conclusion : Sp1 and related factors may play an important role in the regulation of IGF-I gene transcription, through interactions with region V downstream from the major initiation sites in exon 1
Urban et al., Am J Physiol Endocrinol Metab 2002 : The two cell lines expressed Sp1 equally, and IGF-I did not increase expression of either transcription factor
Li et al., Circ Res 2003 : Thus, the transcriptional activation of these two promoters by IGF-1 requires the induction of Sp1 protein
Maor et al., J Endocrinol 2006 (Breast Neoplasms) : In summary, our studies demonstrate that IGF-IR gene transcription in breast cancer cells is controlled by interactions between ERalpha and Sp1
Yuen et al., Oncogene 2007 (Carcinoma, Renal Cell...) : In Sp1-null Drosophila Schneider cells, IGF1R promoter activity was dependent on exogenous Sp1 , and was suppressed by full-length VHL protein ( pVHL ) but only partially by truncated VHL lacking the Sp1 binding motif
Renard et al., J Mol Med (Berl) 2012 : IGF-I increased the binding of Sox9 and Sp1/Sp3 to their cis elements in the enhancer, and we provide the first evidence of Sox9 interaction with the promoter by chromatin immunoprecipitation
Werner et al., Adv Exp Med Biol 1993 (Kidney Neoplasms...) : We have shown that Sp1 positively activates the IGF-I-R promoter
Ohlsson et al., Endocrinology 1998 (Osteosarcoma) : p53 regulates insulin-like growth factor-I (IGF-I) receptor expression and IGF-I induced tyrosine phosphorylation in an osteosarcoma cell line : interaction between p53 and Sp1