Gene interactions and pathways from curated databases and text-mining

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MAPK6 — SOS2

Pathways - manually collected, often from reviews:

  • WikiPathways Insulin Signaling: RAC1/GRB2/SOS1/RAC2/RRAD/GRB14/SOS2/RAF1/HRAS/GRB10 → MINK1/MAP4K4/MAP3K2/MAPK12/MAP3K5/MAPK10/MAP3K3/MAP4K1/MAPK3/MAP2K7/MAPK13/MAP3K1/MAP4K3/MAP2K6/MAP3K8/MAP3K12/MAP2K4/MAPK7/MAPK14/MAP3K11/MAP3K7/MAPK11/MAPK9/MAPK6/MAP3K13/MAP2K3/MAPK4/MAP4K2/MAP2K5/MAP3K10/MAPK1/MAP2K1/MAP3K6/MAP3K4/MAP3K9/MAP4K5/MAP2K2/MAPK8/MAP3K14 (activation)

Text-mined interactions from Literome

Weng et al., Hum Mol Genet 2001 (Breast Neoplasms) : PTEN inhibits insulin stimulated MEK/MAPK activation and cell growth by blocking IRS-1 phosphorylation and IRS-1/Grb-2/Sos complex formation in a breast cancer model
Shindo et al., J Gastroenterol 2006 (Wounds and Injuries) : ( 1 ) SOS activated IkappaB-alpha, but it did not activate ERK1/2 MAPK
Tartaglia et al., Molecular syndromology 2010 : SHP2 ( encoded by PTPN11 ), SOS1 , BRAF, RAF1 and MEK1 positively contribute to RAS-MAPK signaling, and possess complex autoinhibitory mechanisms that are impaired by mutations
Corbalan-Garcia et al., Mol Cell Biol 1996 : Previous studies have demonstrated that growth factor induced Sos phosphorylation occurs at the C-terminal region of the protein and is mediated , in part, by mitogen activated protein ( MAP ) kinase
Lopez-Ilasaca et al., Science 1997 : The tyrosine kinase class of receptors induces mitogen activated protein kinase ( MAPK ) activation through the sequential interaction of the signaling proteins Grb2, Sos , Ras, Raf, and MEK
Nimnual et al., Science 1998 : Ras mediated activation of DH-PH-Sos did not require activation of mitogen activated protein kinase but it was dependent on activation of phosphoinositide 3-kinase