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SIRT1 — SOD2

Pathways - manually collected, often from reviews:

• NCI Pathway Database FoxO family signaling: FOXO1/SIRT1 complex (FOXO1-SIRT1) → MNSOD (SOD2) (transcription, activates) Daitoku et al., Proc Natl Acad Sci U S A 2004*
  Evidence: mutant phenotype, other species

Text-mined interactions from Literome

Tanno et al., J Biol Chem 2010 (Cardiomyopathy, Dilated...) : Induction of manganese superoxide dismutase by nuclear translocation and activation of SIRT1 promotes cell survival in chronic heart failure ... Nuclear but not cytoplasmic SIRT1 induced manganese superoxide dismutase ( Mn-SOD ), which was further enhanced by resveratrol, and increased the resistance of C2C12 myoblasts to oxidative stress
Pardo et al., J Biol Chem 2011 : The NAD dependent protein deacetylase SIRT1 is involved in the protection against oxidative stress by enhancing FOXO-driven Sod2 transcription
Hsu et al., Circulation 2010 (Myocardial Reperfusion Injury) : Sirt1 positively regulates expression of prosurvival molecules, including manganese superoxide dismutase , thioredoxin-1, and Bcl-xL, whereas it negatively regulates the proapoptotic molecules Bax and cleaved caspase-3 ... Sirt1 stimulates the transcriptional activity of FoxO1, which in turn plays an essential role in mediating Sirt1 induced upregulation of manganese superoxide dismutase and suppression of oxidative stress in cardiac myocytes