Gene interactions and pathways from curated databases and text-mining

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MAPK3 — SOD2

Text-mined interactions from Literome

BorrĂ¡s et al., FASEB J 2006 : Phosphorylation of extracellular regulated kinase (ERK)1/2 led to an activation of NFkappaB, as indicated by increased p50 subunit expression in nuclear extracts, and increased mRNA levels of the antioxidant enzyme manganese-superoxide dismutase ( MnSOD )
Nito et al., J Cereb Blood Flow Metab 2008 (Brain Edema...) : Moreover, overexpression of copper/zinc-superoxide dismutase remarkably diminished activation and phosphorylation of both p38 MAPK and cPLA(2) after reperfusion
Gaitanaki et al., J Exp Biol 2008 : Hyperthermia induced p38-MAPK activation was found to be dependent on the Na+/H+ exchanger 1 (NHE1) and was also suppressed by catalase (Cat) and superoxide dismutase ( SOD ) , implicating the generation of reactive oxygen species ( ROS )