Gene interactions and pathways from curated databases and text-mining

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CASP7 — SOD1

Text-mined interactions from Literome

Noshita et al., J Cereb Blood Flow Metab 2001 (Ischemic Attack, Transient) : The current study revealed Mn-SOD might affect cytochrome c translocation and downstream caspase activation in the mitochondrial dependent cell death pathway after transient FCI
Sakudo et al., Biochem Biophys Res Commun 2003 : Re-introduction of Prnp rescued cells from apoptosis, upregulated superoxide dismutase ( SOD ) activity, enhanced superoxide anion elimination, and inhibited caspase-3/9 activation
Yoshida et al., Lab Invest 2003 : Accordingly, neither superoxide dismutase nor N ( G ) -monomethyl-L-arginine had significant effects on HRPE cell apoptosis or caspase-3 activation
Inoue et al., EMBO J 2003 (Amyotrophic Lateral Sclerosis...) : To elucidate the role of caspase-9 in ALS , we examined the effects of an inhibitor of X chromosome linked inhibitor of apoptosis ( XIAP ), a mammalian inhibitor of caspase-3, -7 and -9, and p35, a baculoviral broad caspase inhibitor that does not inhibit caspase-9
Elner et al., Trans Am Ophthalmol Soc 2003 : Accordingly, neither SOD nor NO inhibitors had significant effects on HRPE cell apoptosis or caspase-3 activation
Conde de la Rosa et al., J Hepatol 2006 (MAP Kinase Signaling System...) : ( 3 ) PEG-SOD prevents ERK1/2-, JNK- phosphorylation, caspase activation and apoptosis induced by menadione
Meissner et al., Nat Immunol 2008 (Inflammation...) : Superoxide dismutase 1 regulates caspase-1 and endotoxic shock ... We show here that superoxide dismutase 1 (SOD1) regulates caspase-1 activation
Liang et al., Apoptosis 2009 (Ischemia) : The ATP depletion mediated increase in nuclear fragmentation, an index of apoptosis and activation of caspase-3 was also partially blocked by SOD1 ( P < 0.05 )
GarcĂ­a-Berrocal et al., J Laryngol Otol 2010 (Disease Models, Animal) : Inhibition of caspase-3 activity significantly reduced cochlear heat shock protein 70 expression and total superoxide dismutase activity, and improved auditory brainstem response and auditory steady state response thresholds
Meissner et al., Proc Natl Acad Sci U S A 2010 (Amyotrophic Lateral Sclerosis...) : We report that ALS linked mutant superoxide dismutase 1 (SOD1) activates caspase-1 and IL-1beta in microglia
Yang et al., Int Immunopharmacol 2013 (Disease Models, Animal...) : XN significantly decreased malondialdehyde, potentiated superoxide dismutase and glutathione peroxidase, reduced Bax expression, promoted Bcl-xL and inhibited caspase 3 activity in liver tissues compared with the animals without XN intervention
Fiala et al., American journal of neurodegenerative disease 2013 : The inflammation is driven by stimulation of macrophages by aggregated superoxide dismutase 1 (SOD1) through caspase1 , interleukin 1 (IL1), IL6 and chemokine signaling