Gene interactions and pathways from curated databases and text-mining

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MAPK14 — SOCS5

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: MAPK14 → SOCS5 (directlyDecreases, SOCS5 Activity, MAPK14 Activity)
    Evidence: Pretreatment of VSMC with IL-19 results in a significant reduction in fetal calf stimulated p44/42 and p38 MAPK activation in cultured human VSMC [38]. It was found that this inhibition was mediated by SOCS5 interaction with these MAP kinases, suggesting that in other cell types, other interleukins could inhibit MAPKs by induction of SOCS proteins.