Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
MAPK14
→
SOCS5
(directlyDecreases, SOCS5 Activity, MAPK14 Activity)
Evidence: Pretreatment of VSMC with IL-19 results in a significant reduction in fetal calf stimulated p44/42 and p38 MAPK activation in cultured human VSMC [38]. It was found that this inhibition was mediated by SOCS5 interaction with these MAP kinases, suggesting that in other cell types, other interleukins could inhibit MAPKs by induction of SOCS proteins.