Gene interactions and pathways from curated databases and text-mining

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MAPK14 — SOCS3

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Bode et al., Biol Chem 2001 (Carcinoma, Hepatocellular) : We analyzed the role of MKK6/p38MAPK for IL-6 signal transduction and transcriptional activation of the suppressor of cytokine signaling (SOCS) 3 promoter
Jegalian et al., J Interferon Cytokine Res 2002 : Using two independent approaches, one involving inhibition of specific signaling molecules and the other employing cell lines that express particular EpoR mutants and thereby activate only subsets of signaling cascades, we demonstrate that induction of SOCS1, SOCS2, SOCS3 , and cytokine-inducible SH2 containing protein ( CIS ) in response to EPO stimulation appears to depend on Stat5 but not on mitogen activated protein kinase ( MAPK ) or phosphatidylinositol 3-kinase (PI3K)
Zvonic et al., J Biol Chem 2004 : The effects of CT-1 on SOCS-3 and PPARgamma mRNA were independent of MAPK activation
Qin et al., J Immunol 2007 (MAP Kinase Signaling System) : These results indicate that LPS induced MAPK activation, the production of endogenous IL-10, and STAT-3 activation play critical roles in SOCS-3 expression, which provides for feedback attenuation of cytokine induced immune and inflammatory responses in macrophages and microglia
Puhr et al., Endocr Relat Cancer 2010 (Carcinoma...) : Decreased SOCS-3 protein expression results in increased MAPK phosphorylation, whereas SOCS-3 overexpression leads to a decreased cellular proliferation and migration