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SOCS2 — TLR4

Text-mined interactions from Literome

Hu et al., PloS one 2009 : In conclusion, our results demonstrate that SOCS2 is required for appropriate TLR4 signaling in maturating human DCs via both the MyD88 dependent and -independent signaling pathway
Hu et al., PloS one 2012 : Recent studies suggest that SOCS2 is involved in the regulation of TLR signaling ... In conclusion, our results suggest that TLR4 signaling indirectly increases SOCS2 in late phase mainly via the production of endogenous type I IFN, and that subsequent IFN receptor signaling activates SOCS2 via STAT3 and STAT5
Zadjali et al., FASEB J 2012 (Fatty Liver...) : An inhibitory role of SOCS2 on Toll-like receptor 4 signaling was demonstrated in macrophages obtained from the SOCS2 ( -/- ) and wild-type mice