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UCSC Genome Browser Gene Interaction Graph
Gene interactions and pathways from curated databases and text-mining

◀ Back to STAT3

SOCS1 — STAT3

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Novak et al., Growth Factors 1999 : The expression of the SOCS proteins had no effect on CSF-1 mediated STAT3 tyrosine phosphorylation ; however, SOCS-1 and SOCS-3 reduced the tyrosine phosphorylation of STAT3 in response to IL-6 but did not abolish it
Park et al., Mol Endocrinol 2000 : TSH increases STAT3 mediated promoter activity and also induces endogenous SOCS-1 ( suppressor of cytokine signaling-1 ) gene expression, a known target gene of STAT3 ... The expression of a dominant negative form of STAT3 completely inhibited TSH mediated SOCS-1 expression
Iwamoto et al., Oncogene 2000 (Acute-Phase Reaction) : Forced expression of JAB in v-Src transformed NIH3T3 cells neither suppressed phosphorylation of STAT3 and JAK1/JAK2 nor blocked STAT3-reporter gene activation
Hamanaka et al., Circ Res 2001 (Hypotension) : Forced expression of JAB or CIS3, but not other CISs, directly blocked CT-1 induced STAT3 activation in 293 cells
Federici et al., J Immunol 2002 (Dermatitis, Allergic Contact...) : SOCS1 and SOCS3 overexpression in keratinocyte stable clones inhibited IFN-gamma induced phosphorylation of IFN-gammaR ( alpha ) and activation of STAT1 and STAT3
Kim et al., J Immunol 2003 : TSH induces SOCS-1 and SOCS-3, and TSH mediated SOCS-3 induction was dependent on STAT3
Seki et al., Int J Oncol 2004 (Lung Neoplasms) : Moreover, exogenous expression of either JAB or dominant negative STAT3 in lung carcinoma cell lines led to the suppression of STAT3 phosphorylation and the drastic reduction of anchorage- independent growth of the cells
Lee et al., Mol Cancer Ther 2006 (Carcinoma, Squamous Cell...) : Epigenetic modification of SOCS-1 differentially regulates STAT3 activation in response to interleukin-6 receptor and epidermal growth factor receptor signaling through JAK and/or MEK in head and neck squamous cell carcinomas ... Suppressor of cytokine signaling-1 ( SOCS-1 ) has been implicated recently in the negative regulation of IL-6R/Janus activated kinase ( JAK ) -mediated activation of STAT3, suggesting that SOCS-1 could affect alternative activation of STAT3 by EGFR, IL-6R, and associated kinases ... We investigated whether epigenetic modification of SOCS-1 affects STAT3 activation in response to IL-6R-, EGFR-, JAK-, or mitogen activated protein kinase/extracellular signal regulated kinase kinase ( MEK ) -mediated signal activation ... Pharmacologic inhibitors of JAK and MEK and expression of SOCS-1 following demethylation or transient transfection inhibited STAT3 activation and cell proliferation and induced cell apoptosis in corresponding cell lines
Waiboci et al., J Immunol 2007 : Thus, pJAK2 ( 1001-1013 ) enhanced suboptimal IFN-gamma activity, blocked SOCS-1 induced inhibition of STAT3 phosphorylation in IL-6 treated cells, enhanced IFN-gamma activation site promoter activity, and enhanced Ag-specific proliferation
Park et al., Biochem Biophys Res Commun 2007 (Breast Neoplasms) : SOCS1 induced by NDRG2 expression negatively regulates STAT3 activation in breast cancer cells
Seki et al., J Hepatol 2008 : Here, we investigated this hypothesis by introducing suppressor of cytokine signaling (SOCS)-1 and SOCS3, potent negative regulators of STAT3 signaling, selectively in hepatocytes
Liu et al., J Immunol 2008 (Disease Models, Animal...) : Macrophages in which SOCS3 was knocked down by short interfering RNA responded to IFN-gamma and LPS very differently : they had enhanced STAT3 activity ; induction of macrophage mannose receptor, arginase and SOCS1 ; restoration of IL-4 responsiveness that is inhibited in M1 macrophages ; and decreased synthesis of inflammatory mediators ( NO and IL-6 ) and costimulatory molecule CD86, demonstrating that SOCS3 is essential for M1 activation
Norkina et al., Alcohol Clin Exp Res 2008 : Acute alcohol intake induces SOCS1 and SOCS3 and inhibits cytokine induced STAT1 and STAT3 signaling in human monocytes
Bagnyukova et al., Cell cycle (Georgetown, Tex.) 2008 (Carcinoma, Hepatocellular...) : The results of our study suggest the following model of events in hepatocarcinogenesis : during early stages, overexpression of the Socs1 effectively inhibits TGFbeta- and PDGF induced STAT3 activation, whereas, during the advanced stages of hepatocarcinogenesis, the Socs1 downregulation resulted in loss of its ability to attenuate the signal from the upregulated TGFbeta and PDGFs leading to oncogenic STAT3 activation and malignant cell transformation
Huang et al., Cancer Res 2008 (Brain Neoplasms...) : Moreover, restoration of SOCS-1 expression resulted in the inhibition of Stat3 activation, whereas depletion of SOCS-1 up-regulated Stat3 activation ... These clinical, experimental, and mechanistic findings strongly suggest that increased activation of Stat3 in brain metastatic melanoma cells might be due to decreased SOCS-1 expression
Jager et al., J Neuroimmunol 2011 (Encephalomyelitis, Autoimmune, Experimental) : SOCS1-KIR also blocked IL-23 and IL-17A activation of STAT3
Schneider et al., Eur J Immunol 2011 : IL-27 induced rapid STAT1 and STAT3 signaling, enhanced STAT1 protein levels, and induced SOCS1 and SOCS3 expression in a STAT1 dependent manner by human CD8 ( + ) T cells
de Souza et al., Arch Oral Biol 2011 (Alveolar Bone Loss...) : The SOCS1 and SOCS3 protein expression and activation of STAT1 and STAT3 were increased in earlier periods in the ligature model
Xiong et al., Mol Carcinog 2012 (Colorectal Neoplasms) : Therefore, our data demonstrate that TSA may induce SOCS1 and SOCS3 expression by inducing histone modifications and consequently inhibits JAK2/STAT3 signaling in CRC cells
Shackleford et al., Breast Cancer Res 2011 (Breast Neoplasms) : Stat3 and CCAAT/enhancer binding protein beta ( C/EBP-beta ) regulate Jab1/CSN5 expression in mammary carcinoma cells ... Treatment with the cytokine IL-6 resulted in increased Jab1 expression that was blocked by inhibition of Stat3
Souma et al., Int J Cancer 2012 (MAP Kinase Signaling System...) : In contrast, enforced SOCS-1 expression by adenoviral vector ( AdSOCS-1 ) markedly suppressed STAT3 phosphorylation and proliferation of NUGC-3 and AGS cells in vitro ... Interestingly, the antiproliferative effect of SOCS-1 was attributable not only to the inhibition of STAT3 but also to that of p38 MAPK activity, and chemical inhibitors of JAK/STAT and p38 MAPK signaling effectively suppressed proliferation of these GC cells
Iwahori et al., Int J Cancer 2013 (Mesothelioma...) : SOCS-1 regulated NF-?B and STAT3 signaling to induce apoptosis in MESO-4 and H226 cells
Meng et al., J Hepatol 2012 (Carcinoma, Hepatocellular...) : In addition, IFN? inhibited liver cancer xenograft growth and impaired IL-6 induced STAT3 phosphorylation by inducing SOCS1/3 expression
Masuhara et al., Biochem Biophys Res Commun 1997 : Transient expression of JAB and CIS3, but not other CISs, strongly inhibited leukemia inhibitory factor (LIF) induced STAT3-reporter gene activation in 293 cells