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EPO — SOCS1
Text-mined interactions from Literome
Jegalian et al., J Interferon Cytokine Res 2002
:
Using two independent approaches, one involving inhibition of specific signaling molecules and the other employing cell lines that express particular EpoR mutants and thereby activate only subsets of signaling cascades, we demonstrate that induction of
SOCS1 , SOCS2, SOCS3, and cytokine-inducible SH2 containing protein ( CIS ) in
response to
EPO stimulation appears to depend on Stat5 but not on mitogen activated protein kinase ( MAPK ) or phosphatidylinositol 3-kinase (PI3K)
Dunlop et al., Stem Cells 2007
(Carcinoma, Non-Small-Cell Lung...) :
Compounding this blunted response is impaired SOCS3 induction downstream of
erythropoietin stimulation and an extremely delayed
SOCS1 response