Gene interactions and pathways from curated databases and text-mining

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AKT1 — SNX1

Text-mined interactions from Literome

Okawa et al., Blood 2009 (Leukemia...) : SNX-2112 inhibits cytokine induced Akt and extracellular signal related kinase ( ERK ) activation and also overcomes the growth advantages conferred by interleukin-6, insulin-like growth factor-1, and bone marrow stromal cells
Bachleitner-Hofmann et al., Clin Cancer Res 2011 : In all cell lines, SNX-2112 led to degradation of MET, HER-2, EGFR, and AKT , as well as abrogation of Ras/Raf/MEK/MAPK and PI3K/AKT signaling, followed by complete cell cycle arrest