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PRKAR2A — SMO

Text-mined interactions from Literome

Jia et al., Nature 2004 : Here we show that protein kinase A (PKA) and casein kinase I ( CKI ) regulate Smo cell-surface accumulation and activity in response to Hh. Blocking PKA or CKI activity in the Drosophila wing disc prevents Hh-induced Smo accumulation and attenuates pathway activity, whereas increasing PKA activity promotes Smo accumulation and pathway activation
Su et al., Science signaling 2011 : Phosphorylation of Smo was initiated by adenosine 3',5'-monophosphate ( cAMP ) -dependent protein kinase (PKA) and further enhanced by casein kinase I ( CKI )
Makinodan et al., Exp Dermatol 2012 (Carcinoma, Basal Cell...) : Here we show that PKA activation via the cAMP agonist forskolin is sufficient to completely abolish oncogenic Smo activity in vitro
Ohlmeyer et al., Genes Dev 1997 : In addition, we find that Hh and Smo can stimulate target gene expression at constant Ci levels and that increased PKA activity can induce ectopic Hh target gene expression in a manner that requires Smo and Ci activities but does not involve changes in Ci protein concentration