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SIRT1 — SMAD7

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: SMAD7 — SIRT1 (physical association, affinity chromatography technology) Kume et al., J Biol Chem 2007*
• IRef Biogrid Interaction: SMAD7 — SIRT1 (direct interaction, pull down) Kume et al., J Biol Chem 2007*
• IRef Intact Interaction: SMAD7 — SIRT1 (direct interaction, pull down) Kume et al., J Biol Chem 2007*
• STRING interaction: SIRT1 — SMAD7 (interaction, mapped from intact)
• STRING interaction: SMAD7 — SIRT1 (interaction, mapped from grid mint)

Text-mined interactions from Literome

Kume et al., J Biol Chem 2007 : In mesangial cells, the Smad7 expression level was reduced by SIRT1 overexpression and increased by SIRT1 knockdown ... Finally, SIRT1 overexpression attenuated both Smad7- and TGFbeta induced mesangial cell apoptosis, whereas SIRT1 knockdown enhanced this apoptosis ... Finally, SIRT1 overexpression attenuated both Smad7- and TGFbeta induced mesangial cell apoptosis, whereas SIRT1 knockdown enhanced this apoptosis
Gratchev et al., J Immunol 2008 : Prolonged Smad2 mediated signaling observed in TGF-beta1 treated M2 ( IL-4/GC ) was due to insufficient activity of negative feedback mechanism what can be explained by up-regulation of SIRT1 , a negative regulator of Smad7 , and the retention of TGF-betaRII complex on the cell surface