Gene interactions and pathways from curated databases and text-mining

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IGF2 — SMAD3

Text-mined interactions from Literome

Fanayan et al., J Biol Chem 2002 (Breast Neoplasms) : We previously demonstrated in T47D cells transfected to express the transforming growth factor-beta receptor type II ( TGF-betaRII ) that insulin-like growth factor binding protein-3 ( IGFBP-3 ) could stimulate Smad2 and Smad3 phosphorylation, potentiate TGF-beta1 stimulated Smad phosphorylation, and cooperate with exogenous TGF-beta1 in cell growth inhibition ( Fanayan, S., Firth, S. M., Butt, A. J., and Baxter, R. C. ( 2000 ) J. Biol. Chem. 275, 39146-39151 )
Dong et al., Am J Physiol Endocrinol Metab 2013 (Fibrosis) : Using immunoprecipitation assay, we found an interaction between p-Akt or Akt with Smad3 in wild-type mouse muscles and in C2C12 myoblasts ; importantly, IGF-I increased p-Akt and Smad3 interaction, whereas TGF-ß1 decreased it