Gene interactions and pathways from curated databases and text-mining

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PRKAR2A — SLC9A3

Text-mined interactions from Literome

Bernardo et al., J Clin Invest 1999 : PKA mediated inhibition of NHE3 is mediated by a PDZ motif containing protein, the Na ( + ) /H ( + ) exchanger regulatory factor ( NHE-RF )
Weinman et al., American journal of physiology. Renal physiology 2000 : Signal complex regulation of renal transport proteins : NHERF and regulation of NHE3 by PKA ... This article reviews studies on the regulation of NHE3 by NHERF, PKA , and ezrin and introduces the concept of regulation of renal transporters by signal complexes
Szászi et al., J Biol Chem 2001 : Inhibition of NHE3 by cytochalasin D does not require PKA , because the inhibitory effect is preserved in a mutant NHE3 that is not phosphorylated by PKA and in cells pretreated with the PKA inhibitor H89
Anderson et al., Br J Pharmacol 2003 : Western blot of Caco-2 cell protein demonstrates expression of the NHE regulatory factor NHERF1 ( expression of which is thought to be required for PKA mediated inhibition of NHE3 )
Gomes et al., Eur J Pharmacol 2004 : It is concluded that dopamine D ( 1 ) -mediated inhibition of NHE3 in renal OK cells involves both adenylyl cyclase-PKA and the phospholipase C-PKC pathways, a mechanism similar to that described for Na ( + ), K ( + ) -ATPase
Anderson et al., J Cell Physiol 2005 : Immunocytochemistry localises NHERF1 ( NHE3 regulatory factor 1 ) to the apical portion of Caco-2 cells where it will interact with NHE3 and allow PKA mediated phosphorylation of NHE3
Honegger et al., Proc Natl Acad Sci U S A 2006 : Both PKA and EPAC inhibited NHE3 activity without inducing changes in the expression of the transporter in BBM ... Activation of PKA , but not of EPAC, led to an increase of NHE3 phosphorylation
Kocinsky et al., American journal of physiology. Renal physiology 2007 : To this end, we directly compared PKA induced NHE3 inhibition with site-specific changes in NHE3 phosphorylation in vivo and in vitro ... We conclude that although phosphorylation of NHE3 at serines 552 and 605 is regulated by PKA both in vivo and in vitro, phosphorylation of these sites does not directly alter Na ( + ) /H ( + ) exchange activity
Bezerra et al., American journal of physiology. Renal physiology 2008 : In conclusion, long-term exposure to PTH results in reduction of NHE3 mRNA levels due to a PKA dependent inhibitory effect on the NHE3 promoter and a small reduction of mRNA half-life, and decrease in the total amount of protein which is preceded by endocytosis of the apical surface NHE3
Inoue et al., Am J Physiol Regul Integr Comp Physiol 2012 (Disease Models, Animal...) : In addition, the baseline PKA dependent NHE3 phosphorylation at serine 552 was reduced in renal cortical membranes of rats with HF. Collectively, these results suggest that NHE3 is upregulated in the proximal tubule of HF rats by transcriptional, translational, and posttranslational mechanisms
Lessa et al., American journal of physiology. Renal physiology 2012 : Overall, our data suggest that the inhibitory effect of UGN on NHE3 transport activity in proximal tubule is mediated by activation of both cGMP/PKG and cAMP/PKA signaling pathways which in turn leads to NHE3 phosphorylation and reduced NHE3 surface expression
Moe et al., J Clin Invest 1995 : The present studies examined regulation of NHE-3 by PKA ... PKA activation ( 0.1 mM 8-BrcAMP x 20 min ) inhibited NHE-3 activity by 39 % ( P < 0.01 ) with no change in NHE-3 protein abundance in the plasma membrane ... In summary, acute activation of PKA inhibits NHE-3 activity, an effect that is likely mediated by phosphorylation of its cytoplasmic domain
Zhao et al., J Biol Chem 1999 : A dominant negative PKA-regulatory subunit completely abolished the effect of cAMP on NHE-3 activity demonstrating a role of PKA in the functional regulation of NHE-3 by cAMP ... We conclude that regulation of NHE-3 by PKA in vivo involves complex mechanisms, which include phosphorylation of Ser-552 and Ser-605