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AKT1 — SLC9A3

Text-mined interactions from Literome

Lee-Kwon et al., J Biol Chem 2001 : Constitutively active phosphatidylinositol 3-kinase and AKT are sufficient to stimulate the epithelial Na+/H+ exchanger 3 ... We used an adenoviral infection system to test the possibility that activation of PI 3-kinase or Akt alone is sufficient to stimulate NHE3 activity ... The magnitudes of stimulation of NHE3 by constitutively active PI 3-kinase, PI 3-kinase peptide, and constitutively active Akt were similar to each other ... These results demonstrate that activation of PI 3-kinase or Akt is sufficient to stimulate NHE3 transport activity in PS120/NHE3 cells
Liu et al., Endocrinology 2013 : The phosphorylation ( activation ) of AKT, which is usually upstream of mammalian target of rapamycin in the classic PI3 kinase-AKT-p70S6K signaling pathway, was not affected, suggesting that the gastrin induced phosphorylation of NHE3 and S6 is dependent on both PI3 kinase and PKCa but not AKT