Gene interactions and pathways from curated databases and text-mining

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HIF1A — SLC2A1

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Hayashi et al., J Endocrinol 2004 (Anoxia) : Hypoxia-inducible factor-1 (HIF-1)alpha is involved in the induction of GLUT1 expression in other cells ... The present study was designed to test whether HIF-1alpha is involved in hypoxia induced activation of GLUT1 expression using trophoblast derived human BeWo and rat Rcho-1 cells as models ... Exogeneous HIF-1alpha markedly increased the GLUT1 promoter activity from constructs containing the HRE site, while the GLUT1 promoter constructs lacking the HRE site were not activated by exogenous HIF-1alpha These data demonstrate that GLUT1 is up-regulated under 5 % O2 or in the presence of CoCl2 in the placental cell lines through HIF-1alpha interaction with a consensus HRE site of the GLUT1 promoter
Bernhardt et al., Am J Pathol 2007 (Polycystic Kidney Diseases) : Immunohistochemistry for selected target genes implicated a role for HIF-1alpha in vascular endothelial growth factor and Glut-1 activation and HIF-2alpha in endoglin and EPO stimulation
Baumann et al., Am J Physiol Cell Physiol 2007 (Choriocarcinoma) : The function of HIF-1 was confirmed in experiments where the hypoxic upregulation of GLUT1 and GLUT3 was inhibited by antisense HIF-1alpha
Abaci et al., Am J Physiol Cell Physiol 2010 : Corresponding upregulation of VEGF, ANGPT2, and GLUT-1 was observed in response to HIF-1alpha accumulation, whereas upregulation of ANGPT1 was detected only in hESCs and iPSCs