◀ Back to HIF1A
HIF1A — SLC2A1
Pathways - manually collected, often from reviews:
-
KEGG Pathways in cancer:
EPAS1/HIF1A
→
SLC2A1
(gene expression, expression)
-
KEGG Renal cell carcinoma:
EPAS1/HIF1A
→
SLC2A1
(gene expression, expression)
-
KEGG Renal cell carcinoma:
EPAS1/HIF1A
→
SLC2A1
(gene expression, expression)
-
NCI Pathway Database HIF-1-alpha transcription factor network:
HIF1A/ARNT/Cbp/p300/HDAC7 complex (HIF1A-ARNT-EP300_CREBBP-HDAC7)
→
GLUT1 (SLC2A1)
(transcription, activates)
Hu et al., Mol Cell Biol 2003, Kato et al., J Biol Chem 2004, Iyer et al., Genes Dev 1998
Evidence: mutant phenotype, assay
-
WikiPathways Photodynamic therapy-induced HIF-1 survival signaling:
ARNT/HIF1A
→
PFKL/SLC16A1/LDHA/PKM/PGK1/SLC2A1/HK1/SLC2A3
(activation)
Text-mined interactions from Literome
Hayashi et al., J Endocrinol 2004
(Anoxia) :
Hypoxia-inducible factor-1
(HIF-1)alpha is
involved in the induction of
GLUT1 expression in other cells ... The present study was designed to test whether
HIF-1alpha is
involved in hypoxia induced activation of
GLUT1 expression using trophoblast derived human BeWo and rat Rcho-1 cells as models ... Exogeneous
HIF-1alpha markedly
increased the
GLUT1 promoter activity from constructs containing the HRE site, while the GLUT1 promoter constructs lacking the HRE site were not activated by exogenous HIF-1alpha These data demonstrate that GLUT1 is up-regulated under 5 % O2 or in the presence of CoCl2 in the placental cell lines through HIF-1alpha interaction with a consensus HRE site of the GLUT1 promoter
Bernhardt et al., Am J Pathol 2007
(Polycystic Kidney Diseases) :
Immunohistochemistry for selected target genes implicated a
role for
HIF-1alpha in vascular endothelial growth factor and
Glut-1 activation and HIF-2alpha in endoglin and EPO stimulation
Baumann et al., Am J Physiol Cell Physiol 2007
(Choriocarcinoma) :
The function of HIF-1 was confirmed in experiments where the hypoxic upregulation of
GLUT1 and GLUT3 was
inhibited by antisense
HIF-1alpha
Abaci et al., Am J Physiol Cell Physiol 2010
:
Corresponding upregulation of VEGF, ANGPT2, and
GLUT-1 was observed in
response to
HIF-1alpha accumulation, whereas upregulation of ANGPT1 was detected only in hESCs and iPSCs