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AKT1 — SIRT6
Text-mined interactions from Literome
Xiao et al., J Biol Chem 2010
(Hypoglycemia...) :
We further demonstrated that
SIRT6 negatively
regulates AKT phosphorylation at Ser-473 and Thr-308 through inhibition of multiple upstream molecules, including insulin receptor, IRS1, and IRS2 ... The absence of
SIRT6 , consequently,
enhances insulin signaling and activation of
AKT , leading to hypoglycemia
Sundaresan et al., Nat Med 2012
(Cardiomegaly...) :
The sirtuin
SIRT6 blocks
IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun