Gene interactions and pathways from curated databases and text-mining

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AKT1 — SIRT6

Text-mined interactions from Literome

Xiao et al., J Biol Chem 2010 (Hypoglycemia...) : We further demonstrated that SIRT6 negatively regulates AKT phosphorylation at Ser-473 and Thr-308 through inhibition of multiple upstream molecules, including insulin receptor, IRS1, and IRS2 ... The absence of SIRT6 , consequently, enhances insulin signaling and activation of AKT , leading to hypoglycemia
Sundaresan et al., Nat Med 2012 (Cardiomegaly...) : The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun