Gene interactions and pathways from curated databases and text-mining

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AKT1 — SIRT1

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Ni et al., Proc Natl Acad Sci U S A 2007 (Insulin Resistance) : Resveratrol, an activator of Sirt1 , increases the transcriptional activity of FoxO1 and triggers Akt phosphorylation in heart
Ota et al., Arterioscler Thromb Vasc Biol 2008 (Diabetes Mellitus, Experimental) : Cilostazol increased phosphorylation of Akt at Ser ( 473 ) and of endothelial nitric oxide synthase (eNOS) at Ser ( 1177 ), with a dose dependent increase in Sirt1 expression
Fröjdö et al., Mol Cell Endocrinol 2011 (Diabetes Mellitus, Type 2...) : In muscle cells and HEK293 cells, downregulation of SIRT1 reduced , while overexpression increased, insulin induced PKB activatory phosphorylation
Sundaresan et al., Science signaling 2011 (Cardiomegaly...) : The deacetylase SIRT1 promotes membrane localization and activation of Akt and PDK1 during tumorigenesis and cardiac hypertrophy
Ye et al., Cardiovasc Drugs Ther 2011 (Diabetes Mellitus, Experimental...) : Both AL and VA reduced myocardial AT1R levels, without affecting AT2R levels, and increased the expression of Sirt1 and PGC-1a with increased phosphorylation of Akt and eNOS
Chen et al., J Nutr Biochem 2012 (Second Messenger Systems) : By using small interfering RNAs of Sirt1, adenosine-monophosphate activated protein kinase ( AMPK ) a, survivin and the AMPK agonist ( 5-aminoimidazole-4-carboxamide 1-ß-D-ribofuranoside ) and specific inhibitors for protein kinase B ( AKT ) or caspases, it was demonstrated that activation of Sirt1 inhibited AKT activation and further decreased the expression of survivin
Lu et al., J Biol Chem 2013 (Insulin Resistance) : In line with the in vivo results, insulin induced AKT and FoxO1 phosphorylation were potentiated by inhibition of Sirt1 in a cultured hypothalamic cell line