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AKT1 — SIRT1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
AKT1
—
SIRT1
(physical association, affinity chromatography technology)
Sundaresan et al., Science signaling 2011*
-
IRef Biogrid Interaction:
AKT1
—
SIRT1
(direct interaction, enzymatic study)
Sundaresan et al., Science signaling 2011*
-
IRef Intact Interaction:
AKT1
—
SIRT1
(physical association, anti bait coimmunoprecipitation)
Sundaresan et al., Science signaling 2011*
-
IRef Intact Interaction:
AKT1
—
SIRT1
(direct interaction, pull down)
Sundaresan et al., Science signaling 2011*
-
IRef Intact Interaction:
AKT1
—
SIRT1
(physical association, anti tag coimmunoprecipitation)
Sundaresan et al., Science signaling 2011*
Text-mined interactions from Literome
Ni et al., Proc Natl Acad Sci U S A 2007
(Insulin Resistance) :
Resveratrol, an activator of
Sirt1 , increases the transcriptional activity of FoxO1 and
triggers Akt phosphorylation in heart
Ota et al., Arterioscler Thromb Vasc Biol 2008
(Diabetes Mellitus, Experimental) :
Cilostazol
increased phosphorylation of
Akt at Ser ( 473 ) and of endothelial nitric oxide synthase (eNOS) at Ser ( 1177 ), with a dose dependent increase in
Sirt1 expression
Fröjdö et al., Mol Cell Endocrinol 2011
(Diabetes Mellitus, Type 2...) :
In muscle cells and HEK293 cells, downregulation of
SIRT1 reduced , while overexpression increased, insulin induced
PKB activatory phosphorylation
Sundaresan et al., Science signaling 2011
(Cardiomegaly...) :
The deacetylase
SIRT1 promotes membrane localization and activation of
Akt and PDK1 during tumorigenesis and cardiac hypertrophy
Ye et al., Cardiovasc Drugs Ther 2011
(Diabetes Mellitus, Experimental...) :
Both AL and VA reduced myocardial AT1R levels, without affecting AT2R levels, and
increased the expression of
Sirt1 and PGC-1a with increased phosphorylation of
Akt and eNOS
Chen et al., J Nutr Biochem 2012
(Second Messenger Systems) :
By using small interfering RNAs of Sirt1, adenosine-monophosphate activated protein kinase ( AMPK ) a, survivin and the AMPK agonist ( 5-aminoimidazole-4-carboxamide 1-ß-D-ribofuranoside ) and specific inhibitors for protein kinase B ( AKT ) or caspases, it was demonstrated that activation of
Sirt1 inhibited
AKT activation and further decreased the expression of survivin
Lu et al., J Biol Chem 2013
(Insulin Resistance) :
In line with the in vivo results, insulin induced
AKT and FoxO1 phosphorylation were
potentiated by inhibition of
Sirt1 in a cultured hypothalamic cell line