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CREB1 — SIK2
Text-mined interactions from Literome
Takemori et al., J Steroid Biochem Mol Biol 2008
:
Regulation of
CREB mediated gene expression by
salt inducible kinase ...
SIK represses the activity of
CRE binding protein ( CREB ) by phosphorylating a CREB-specific co-activator transducer of regulated CREB activity ( TORC )
Takemori et al., Endocr J 2009
:
Meanwhile,
SIK1 represses the transcription factor cAMP-response element binding protein (
CREB ) by phosphorylating its co-activator transducer of regulated CREB activity ( TORC )
Jefcoate et al., Mol Cell Endocrinol 2011
:
A second protein,
CREB regulated transcription coactivator ( TORC/CRTC ), enhances this recruitment, but is
inhibited by
salt inducible kinase ( SIK )
Sasaki et al., Neuron 2011
:
These findings suggest that
SIK2 plays critical roles in neuronal survival, is modulated by CaMK I/IV, and
regulates CREB via TORC1