Gene interactions and pathways from curated databases and text-mining

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AKT1 — SIGMAR1

Text-mined interactions from Literome

Bhuiyan et al., Expert Opin Ther Targets 2009 (Hypertrophy, Left Ventricular) : DHEA treatment protects against PO-induced cardiac injury via upregulation of Sig-1R and stimulation of Sig-1R mediated Akt-eNOS signaling
Li et al., Neuropharmacology 2010 : These findings suggest that DHEA prevents the Abeta ( 25-35 ) -impaired survival and dendritic growth of newborn neurons through a sigma(1) receptor mediated modulation of PI3K-Akt-mTOR-p70S6k signaling
Bhuiyan et al., Cardiovasc Ther 2011 (Hypertrophy, Left Ventricular) : Dehydroepiandrosterone mediated stimulation of sigma-1 receptor activates Akt-eNOS signaling in the thoracic aorta of ovariectomized rats with abdominal aortic banding
Bhuiyan et al., Expert Opin Ther Targets 2010 (Hypertrophy, Left Ventricular) : Fluvoxamine treatment protects PO-induced cardiac injury via upregulation of Sig-1R and stimulation of Sig-1R mediated Akt-eNOS signaling in ovariectomized rats
Tagashira et al., Yakugaku Zasshi 2012 (Cardiomegaly...) : Our findings suggest that fluvoxamine protects heart against TAC induced cardiac dysfunction via upregulation of Sig-1R and stimulation of Sig-1R mediated Akt-eNOS signaling in mice
Bhuiyan et al., J Pharmacol Sci 2013 (Heart Failure) : Our findings suggest that SSRIs such as fluvoxamine protect against PO- and TAC induced cardiac dysfunction by upregulating sigma-1 receptor expression and stimulating sigma-1 receptor mediated Akt-eNOS signaling