Bhuiyan et al., Expert Opin Ther Targets 2009
(Hypertrophy, Left Ventricular) :
DHEA treatment protects against PO-induced cardiac injury via upregulation of Sig-1R and stimulation of Sig-1R mediated Akt-eNOS signaling
Li et al., Neuropharmacology 2010
:
These findings suggest that DHEA prevents the Abeta ( 25-35 ) -impaired survival and dendritic growth of newborn neurons through a sigma(1) receptor mediated modulation of PI3K-Akt-mTOR-p70S6k signaling
Bhuiyan et al., Cardiovasc Ther 2011
(Hypertrophy, Left Ventricular) :
Dehydroepiandrosterone mediated stimulation of sigma-1 receptor activates Akt-eNOS signaling in the thoracic aorta of ovariectomized rats with abdominal aortic banding
Bhuiyan et al., Expert Opin Ther Targets 2010
(Hypertrophy, Left Ventricular) :
Fluvoxamine treatment protects PO-induced cardiac injury via upregulation of Sig-1R and stimulation of Sig-1R mediated Akt-eNOS signaling in ovariectomized rats
Tagashira et al., Yakugaku Zasshi 2012
(Cardiomegaly...) :
Our findings suggest that fluvoxamine protects heart against TAC induced cardiac dysfunction via upregulation of Sig-1R and stimulation of Sig-1R mediated Akt-eNOS signaling in mice
Bhuiyan et al., J Pharmacol Sci 2013
(Heart Failure) :
Our findings suggest that SSRIs such as fluvoxamine protect against PO- and TAC induced cardiac dysfunction by upregulating sigma-1 receptor expression and stimulating sigma-1 receptor mediated Akt-eNOS signaling