Gene interactions and pathways from curated databases and text-mining

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AKT1 — SHC1

Text-mined interactions from Literome

Baughn et al., J Virol 2005 (Cell Transformation, Viral) : In contrast to effects on proliferation, survival of the cells and activation of Akt were not affected by expression of DN Shc
Lockyer et al., J Immunol 2007 : Restoring STAT5 activity via a heterologous receptor rescued Shc induced Akt/p70S6 kinase activity and cell proliferation with kinetics consistent with a transcriptional mechanism
Lee et al., J Biol Chem 2010 : OSS induced activation of PI3K/Akt/mTOR/p70S6K and cell proliferation were inhibited by specific antibodies or small interference RNAs of alpha ( v ) beta ( 3 ) and beta ( 1 ) integrins and by dominant negative mutants of Shc ( Shc-SH2 ) and focal adhesion kinase ( FAK ) ( FAK ( F397Y ) )