Gene interactions and pathways from curated databases and text-mining

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AKT1 — SH2B1

Text-mined interactions from Literome

Wang et al., J Biol Chem 2004 : To gain insight into the mechanism by which the adapter protein SH2-B promotes nerve growth factor (NGF) mediated neuronal differentiation and survival, the effect of SH2-B on the serine/threonine kinase Akt/protein kinase B and downstream effector proteins was examined ... To gain insight into the mechanism by which the adapter protein SH2-B promotes nerve growth factor (NGF) mediated neuronal differentiation and survival, the effect of SH2-B on the serine/threonine kinase Akt/protein kinase B and downstream effector proteins was examined
Yoshiga et al., Mol Endocrinol 2007 : Insulin induced Akt activation and the phosphorylation of forkhead transcription factor ( FKHR/Foxo1 ), a negative regulator of PPARgamma transcription, were up-regulated by SH2-B overexpression, but reduced in SH2-B-deficient MEFs
Lu et al., Journal of molecular signaling 2010 : Overexpressing the adaptor protein SH2B1ß enhanced H2O2 induced PI3K-AKT and MEK-ERK1/2 signaling, reduced nucleus localized FoxOs and the expression of a pro-apoptotic gene, FasL