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AKT1 — SH2B1
Text-mined interactions from Literome
Wang et al., J Biol Chem 2004
:
To gain insight into the mechanism by which the adapter protein SH2-B promotes nerve growth factor (NGF) mediated neuronal differentiation and survival, the
effect of
SH2-B on the serine/threonine kinase
Akt/protein kinase B and downstream effector proteins was examined ... To gain insight into the mechanism by which the adapter protein SH2-B promotes nerve growth factor (NGF) mediated neuronal differentiation and survival, the
effect of
SH2-B on the serine/threonine kinase
Akt/protein kinase B and downstream effector proteins was examined
Yoshiga et al., Mol Endocrinol 2007
:
Insulin induced
Akt activation and the phosphorylation of forkhead transcription factor ( FKHR/Foxo1 ), a negative regulator of PPARgamma transcription, were
up-regulated by
SH2-B overexpression, but reduced in SH2-B-deficient MEFs
Lu et al., Journal of molecular signaling 2010
:
Overexpressing the adaptor protein
SH2B1ß enhanced H2O2 induced
PI3K-AKT and MEK-ERK1/2 signaling, reduced nucleus localized FoxOs and the expression of a pro-apoptotic gene, FasL