Gene interactions and pathways from curated databases and text-mining

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PRKDC — SETD2

Text-mined interactions from Literome

Um et al., Exp Mol Med 2004 (Neoplasms) : In this study, we revealed that DNA dependent protein kinase (DNA-PK) , which plays a crucial role in DNA double strand break repair, would be involved in regulation of hypoxia inducible factor-1 (HIF-1)
Bouquet et al., J Cell Sci 2011 : Importantly, in using either silenced DNA-PK cells or cells exposed to a specific DNA-PK inhibitor ( NU7026 ), we demonstrated that hypoxic DNA-PK activation positively regulates the key transcription factor HIF-1 and one subsequent target gene, GLUT1