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IGF1 — SETD2

Text-mined interactions from Literome

Treins et al., Mol Endocrinol 2005 : We show that IGF-I stimulates HIF-1alpha accumulation, HIF-1alpha nuclear translocation, and HIF-1 activity by regulation of HIF-1alpha expression through a posttranscriptional mechanism ... In addition, we demonstrate that IGF-I stimulates HIF-1 activity through phosphatidylinositol-3-kinase/ mammalian target of rapamycin and MAPK dependent signaling pathways leading to VEGF ( vascular endothelial growth factor ) mRNA expression
Dimova et al., Thromb Haemost 2005 (MAP Kinase Signaling System...) : Furthermore, IGF-1 enhanced HIF-1alpha protein levels and HIF-1 DNA binding to each HRE, E4 and E5 as shown by EMSA
Sutton et al., Oncogene 2007 : Selective inhibition of MEK1/2 reveals a differential requirement for ERK1/2 signalling in the regulation of HIF-1 in response to hypoxia and IGF-1 ... Interestingly however, the highly selective MEK1/2 inhibitor PD184352 did not inhibit HIF-1 activity or vascular endothelial growth factor ( VEGF ) induced in response to hypoxia but blocked HIF-1alpha protein and HIF-1 activity induced by IGF-1 stimulation without affecting HIF-1alpha mRNA levels ... Taken together, our data suggest that although ERK1/2 signalling is important for HIF-1alpha induction and HIF-1 activity in response to IGF-1 , it is dispensable for the induction of HIF-1alpha and activation of HIF-1 in response to hypoxia
Thomas et al., Prostate 2009 (Prostatic Neoplasms) : Furthermore, HIF-1alpha suppression attenuated the serum deprivation mediated increase in Akt and IGF-IR activation
Gariboldi et al., Biochem Pharmacol 2010 (Glioblastoma) : Our results show that exogenous IGF-I causes IGF1R and STAT3 activation, and increases HIF1alpha protein levels and HIF1 trascriptional activity, inducing VEGF release ; a similar response, mediated by IGF-II release, is observed following HIF1alpha stabilization
Sinha et al., Cell Signal 2011 (Glioblastoma...) : As HIF-1a links inflammatory and oncogenic pathways in GBM, we investigated whether IGF-1 affects HIF-1a? to regulate inflammatory response in glioma cells under normoxia ... Interestingly, while synthetic CpG containing oligodeoxynucleotide TLR9 agonist ( CpG DNA ) decreased IGF-1 mediated increase in HIF-1a activity, siRNA mediated knockdown of HIF-1a decreased TLR9 levels
Yu et al., Brain Res 2012 : Using echinomycin, a HIF-1 inhibitor, and HIF-1a siRNA, we demonstrated IGF-1 induced GLUT3 expression through HIF-1a in neuronal PC12 cells ... Moreover, IGF-1 stimulated HIF-1a and GLUT3 protein expression through phosphatidylinositol 3-kinase (PI3K)/Akt/mTOR dependent pathways ... Moreover, IGF-1 stimulated HIF-1a and GLUT3 protein expression through phosphatidylinositol 3-kinase (PI3K)/Akt/mTOR dependent pathways
Sartori-Cintra et al., Clinics (Sao Paulo) 2012 (Osteoarthritis) : Regulation of hypoxia-inducible factor-1a (HIF-1a) expression by interleukin-1ß (IL-1 ß), insulin-like growth factors I (IGF-I) and II ( IGF-II ) in human osteoarthritic chondrocytes ... IL-1ß upregulated the levels of HIF-1a protein post-transcriptionally, whereas IGF-I increased HIF-1a at the transcript level ... In contrast, IGF-II did not affect the protein or gene expression levels of HIF-1a
Piecewicz et al., PloS one 2012 : We confirmed that IGF-IGFR1 signaling stabilizes HIF1a and leads to up-regulation of VEGF during vasculogenesis in embryoid bodies
Yoon et al., J Assist Reprod Genet 2013 : Effects of oxygen tension and IGF-I on HIF-1a protein expression in mouse blastocysts
Hinkel et al., Curr Vasc Pharmacol 2013 (Constriction, Pathologic...) : Hif-1a , a master regulator of ischemia-responsive gene induction, controls pro-angiogenic gene expression of VEGF-A, flt-1, IGF-1 and erythropoietin, rendering its overexpression an attractive tool for therapeutic neovascularization
Dal Monte et al., Exp Eye Res 2013 (Disease Models, Animal...) : Propranolol ophthalmic solutions reduced VEGF and IGF-1 up-regulation in response to hypoxia and drastically inhibited HIF-1a accumulation and STAT3 phosphorylation
Kurabayashi et al., PloS one 2013 : Because the effect of IGF-I on HIF-1a protein synthesis is mediated by IGF-IR , our results indicated that VHL inactivation accelerated hepatic glucose storage through the upregulation of IGF-IR and GLUT1 and that IGF-IR was a key regulator in VHL-deficient hepatocytes ... Because the effect of IGF-I on HIF-1a protein synthesis is mediated by IGF-IR, our results indicated that VHL inactivation accelerated hepatic glucose storage through the upregulation of IGF-IR and GLUT1 and that IGF-IR was a key regulator in VHL-deficient hepatocytes