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AKT1 — SETD2
Text-mined interactions from Literome
Kietzmann et al., Blood 2003
(Anoxia) :
Furthermore, insulin and the active
PKB enhanced all 3 HIF alpha-subunit protein levels and
HIF-1 DNA binding activity, as shown by electrophoretic mobility shift assays ( EMSAs )
Figueroa et al., Exp Hematol 2002
(Anoxia) :
Overexpression of constitutively active
AKT resulted in increased NF-kappaB and
HIF-1 transactivation
Roth et al., J Biol Chem 2004
:
Transfection experiments and gel shift assays show that this element is able to bind
hypoxia-inducible factor-1 (HIF-1) in a hypoxia- and
PKB dependent manner
Li et al., Cancer Res 2004
:
Inhibition of PI-3K,
Akt , and p70 ( S6k ) by overexpression of a dominant negative mutant of PI-3K ( Deltap85 )
impaired nickel induced
HIF-1 transactivation ... Furthermore, an overexpression of the dominant negative Akt mutant ( Akt-T308A/S473A ) blocked nickel induced
Akt phosphorylation and
HIF-1 transactivation , whereas inhibition of p70 ( S6k ) activation by pretreatment of cells with rapamycin did not show significant inhibitory effects on HIF-1 transactivation induced by nickel compounds
Tanaka et al., Cancer Res 2006
(Anoxia...) :
Conversely, HIF-1alpha knockdown by short interfering RNA in the HCC cell line resulted in decreased expression of activated Akt together with the HIF-1 target genes, indicating that
Akt activation is reversely
dependent on
HIF-1 activation ... However, Akt was not activated by IGF-II or EGF in the HIF-1alpha knockdown cells, indicating that expression of the
HIF-1 target genes is
necessary for the
Akt activation
Carver et al., Am J Respir Cell Mol Biol 2007
:
Akt mediated activation of
HIF-1 in pulmonary vascular endothelial cells by S-nitrosoglutathione ... We speculate that gammaGT dependent activation of
Akt and subsequent
activation of
HIF-1 in vascular beds may be relevant to the regulation of HIF-1 dependent gene expression in conditions associated with oxyhemoglobin deoxygenation, as opposed to profoundly low Po ( 2 ), in the pulmonary vasculature
Tomita et al., Biochem J 2007
(Leukemia, T-Cell) :
The results of the present study suggest that
PI3K/Akt activation induced by Tax
leads to activation of
HIF-1
Jiang et al., Curr Cancer Drug Targets 2008
(Neovascularization, Pathologic) :
Recent studies have shown that
AKT activation is necessary and
sufficient to regulate VEGF and
HIF-1 expression in human cancer cells ... It was found that
AKT activation
induces VEGF and
HIF-1 expression through its two downstream molecules HDM2 and p70S6K1
Alam et al., Endocrinology 2009
:
These results indicate that FSH stimulated
HIF-1 activation leading to up-regulation of targets such as vascular endothelial growth factor
requires not only
PI3-kinase/AKT mediated activation of mammalian target of rapamycin as well as phosphorylation of FOXO1 and possibly MDM2 but also a protein ( kinase ) activity that is inhibited by the classic ERK kinase inhibitor PD98059 but not ERK1/2 or 5
Thomas et al., Prostate 2009
(Prostatic Neoplasms) :
Furthermore,
HIF-1alpha suppression
attenuated the serum deprivation mediated increase in
Akt and IGF-IR activation
Jiang et al., Adv Cancer Res 2009
(Neoplasms...) :
PI3K signaling regulates tumor growth and angiogenesis by activating
AKT and other targets, and by
inducing HIF-1 and VEGF expression
He et al., Rheumatol Int 2011
(Arthritis, Rheumatoid) :
TNFa- or hypoxia induced secretion of VEGF and IL-8 and expression of HIF-1a were hampered by treatment with the PI3 kinase inhibitor LY294002, suggesting that inhibition of PI3
kinase/Akt activation might
inhibit VEGF and IL-8 secretion and
HIF-1a expression induced by TNFa or hypoxia
Luwor et al., Cancer Lett 2011
(Carcinoma, Squamous Cell...) :
Compared with corresponding control cells, A431-Ras cells exhibited marked resistance to the EGFR inhibitors cetuximab and gefitinib, reducing inhibition of
Akt and Erk phosphorylation,
inhibition of
HIF-1a expression and transcriptional activity, and antitumor effects in vitro and in vivo
Suzuki et al., Mol Med Report 2008
:
In addition, our study revealed that neither the
PI3K/Akt nor the p53 signaling pathway is
required for Zeb induced
HIF-1a degradation
Chern et al., Planta Med 2011
(Cerebral Infarction...) :
In BV-2 cells, OGD induced ROS and nitric oxide production by upregulating NOX2 and iNOS via the phosphatidylinositol-3-kinase
(PI3K)/AKT dependent NF- ?B and
HIF-1 a pathways, and these changes were suppressed by andrographolide and LY294002 ... Our results indicate that andrographolide reduces NOX2 and iNOS expression possibly by impairing
PI3K/AKT dependent NF- ?B and
HIF-1 a activation
Liu et al., PloS one 2011
(Neovascularization, Pathologic) :
The
AKT and ERK inhibitors, LY294002 and U0126,
suppressed HIF-1a and VEGF expression and angiogenesis
Li et al., Mol Cell Biochem 2013
(Arthritis, Experimental...) :
We demonstrated that hypoxia induced EMT was accompanied by increased
hypoxia-inducible factor (HIF)-1a expression and
activation of
Akt
He et al., Cancer Chemother Pharmacol 2013
(Carcinoma, Non-Small-Cell Lung...) :
Meanwhile, HPV-16 E6 and E7 oncoproteins
HIF-1a-dependently enhanced
Akt activation in A549 cells, which was suppressed by EGCG ... EGCG inhibited HPV-16 oncoprotein induced angiogenesis conferred by NSCLC through the inhibition of HIF-1a protein expression and
HIF-1a dependent expression of VEGF, IL-8, and CD31 as well as
activation of
Akt , suggesting that HIF-1a may be a potential target of EGCG against HPV related NSCLC angiogenesis
Fu et al., PloS one 2013
:
BBR also downregulated
HIF-1a and VEGF expression and
inhibited Akt and ERK phosphorylation