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Proteinase inhibitor 9 (PI-9) inhibits caspase-1 ( interleukin (IL)-1beta converting enzyme ) and granzyme B, thereby regulating production of the pro-inflammatory cytokine IL-1beta and susceptibility to granzyme B-induced apoptosis
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Inhibition of PI-9 by small inhibitory RNA decreased M. tuberculosis induced expression of the antiapoptotic molecule Bcl-2 and resulted in a corresponding increase in production of caspase 3, a terminal effector molecule of apoptosis