Gene interactions and pathways from curated databases and text-mining

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CASP5 — SEC14L2

Text-mined interactions from Literome

Cygnar et al., Genetics 2005 : Loss of Tap42 ultimately results in increased JNK signaling, caspase activation, and cell death
Toh et al., Nucleic Acids Res 2008 : TAp73beta and DNp73beta activate the expression of the pro-survival caspase-2S
Muppani et al., Oncotarget 2011 (Lung Neoplasms...) : Here, we report that TAp73alpha represses caspase-2 enzymatic activity and by this means reduce caspase-2 induced Bax activation, loss of mitochondrial transmembrane potential and resulting apoptosis ... The inhibitory effect on caspase-2 requires the presence of the DNA binding domain and SAM domain region of TAp73alpha