Gene interactions and pathways from curated databases and text-mining

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CXCR4 — S1PR1

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Ryser et al., Mol Immunol 2008 : S1P(1) overexpression resulted in reduced CXCR4 surface expression levels and strong inhibition of SDF-1 dependent ERK1/2 phosphorylation and Ca ( 2+ ) flux
Möhle et al., Ann N Y Acad Sci 2012 : Stimulation of S1P1 or C3aR has been shown to activate CXCR4 in HPCs that may sensitize CXCR4 dependent stem cell homing