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MAPK14 — S100A9
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
MAPK14
→
S100A9
(increases, S100A9 Activity)
Evidence: S100-A9 binds the transcription factors NF-kB and P53, and activates the P38 and ERK MAPK kinases and the receptor for advanced glycated end products (RAGE) (50).
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Schenten et al., Biochim Biophys Acta 2010
:
Inhibition of p38 MAPK activity and S100A9 phosphorylation by bromoenol lactone, a selective inhibitor of iPLA ( 2 ), indicated that p38
MAPK mediated
S100A9 phosphorylation is dependent on iPLA ( 2 )
Bando et al., Biochim Biophys Acta 2013
:
Modeled using human epidermal keratinocytes ( HaCaT cells ), IL-1a stimulated the phosphorylation of p38
MAPK and
induced S100A9 expression, which was blocked by IL-1 receptor antagonist, RNAi suppression of p38, or a p38 MAPK inhibitor