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NOTCH4 — RUNX2

Text-mined interactions from Literome

Zayzafoon et al., J Biol Chem 2004 (Bone Neoplasms...) : Finally, we show that Notch and ERK activation are essential for Runx2 DNA binding activity and osteocalcin gene expression in C4-2B cells in response to osteogenic induction
Garg et al., Nature 2005 (Calcinosis...) : Consistent with the valve calcification phenotype, Notch1 transcripts were most abundant in the developing aortic valve of mice, and Notch1 repressed the activity of Runx2 , a central transcriptional regulator of osteoblast cell fate
Watanabe et al., PLoS Genet 2013 : Moreover, inhibition of Notch signaling did not affect the action of MAML1 on Runx2 , suggesting that the activation of Runx2 by MAML1 may be caused in a Notch independent manner