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RSPO2 — WNT11

Text-mined interactions from Literome

Kazanskaya et al., Dev Cell 2004 : R-Spondin2 is a secreted activator of Wnt/beta-catenin signaling and is required for Xenopus myogenesis ... Antisense Morpholino experiments in Xenopus embryos and RNAi experiments in HeLa cells reveal that Rspo2 is required for Wnt/beta-catenin signaling
Binnerts et al., Proc Natl Acad Sci U S A 2007 : R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6
Friedman et al., J Biol Chem 2009 : Wnt11 also increases expression of Rspo2 ( R-spondin 2 ), a secreted factor known to enhance Wnt signaling ... Antagonism of T-cell factor ( Tcf ) /beta-catenin signaling with dominant negative Tcf blocks Wnt11 mediated expression of Dmp1, Phex, and Rspo2 and decreases mineralization
Hao et al., Nature 2012 (Colorectal Neoplasms...) : These data suggest that R-spondin enhances Wnt signalling by inhibiting ZNRF3
Jin et al., Int J Biochem Cell Biol 2012 (Bone Diseases...) : Recent advances in the RSPO research field revealed some of the in vivo functions of RSPOs and provided new information regarding the mechanistic roles of RSPO activity in regulation of WNT signaling