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RPS6KB1 — TSC1
Pathways - manually collected, often from reviews:
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OpenBEL Selventa BEL large corpus:
RPS6KB1
→
Complex of TSC1-TSC2
(decreases, TSC1/TSC2 Activity, RPS6KB1 Activity)
Evidence: Furthermore, in insulin- or serum-stimulated cells, activation of p70S6K is inhibited by expression of the Tsc1-Tsc2 complex [54,55]. This finding demonstrates that the introduction of a genetic inhibitor of mTOR, downstream of Akt1, inhibits the activation of p70S6K, adding genetic evidence for an Akt1-mTOR-p70S6K pathway.
Text-mined interactions from Literome
Tee et al., Proc Natl Acad Sci U S A 2002
(Tuberous Sclerosis) :
Second, the activity of S6K1 was repressed by coexpression of hamartin and tuberin, but the activity of rapamycin-resistant mutants of S6K1 were not affected, implicating mTOR in the
TSC mediated inhibitory effect on
S6K1
Jaeschke et al., J Cell Biol 2002
(Tuberous Sclerosis) :
Although activation of wild-type S6K1 and cell proliferation in TSC2-deficient cells is dependent on the mammalian target of rapamycin (mTOR), by using an S6K1 variant ( GST-DeltaC-S6K1 ), which is uncoupled from mTOR signaling, we demonstrate that
TSC1-2 does not
inhibit S6K1 via mTOR