Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
RPS6KA5
→
MAPK14
(increases, RPS6KA5 Activity)
Abécassis et al., J Biol Chem 2004* Evidence: We report here that inhibition of the p38alpha isoform suppressed the ability of Smad3 to mediate TGF-beta-induced transcriptional responses. The inhibition of p38 activity blocked TGF-beta-mediated phosphorylation of the MSK1 kinase, a substrate of p38 that plays an important role in the remodeling of chromatin.
OpenBEL Selventa BEL large corpus:
RPS6KA5
→
MAPK14
(directlyIncreases, RPS6KA5 Activity)
Evidence: PhosphoElm data from PMID 15212693