Gene interactions and pathways from curated databases and text-mining

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MAPK3 — RPS6KA1

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Butcher et al., Eur J Neurosci 2004 (MAP Kinase Signaling System) : In vivo pharmacological inhibition of light induced MAPK pathway activation blocked RSK-1 phosphorylation, indicating that RSK-1 activity is regulated by the MAPK pathway
Larrea et al., Proc Natl Acad Sci U S A 2009 (MAP Kinase Signaling System) : Because RSK1 is also activated by MAPK , the increased cell motility and metastatic potential of cancer cells with PI3K and/or MAPK pathway activation may result in part from RSK1 activation, leading to accumulation of p27T198 in the cytoplasm, p27 : RhoA binding, inhibition of RhoA/Rock pathway activation, and loss of actomyosin stability