◀ Back to MAPK3
MAPK3 — RPS6KA1
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
RPS6KA1
→
MAPK3
(increases, MAPK3 Activity, RPS6KA1 Activity)
Zhao et al., J Biol Chem 1996*
Evidence: The kinase activity of RSK1 or RSK2 was enhanced by in vitro incubation with ERK1
-
BioCarta transcription factor creb and its extracellular signals:
ERK1/ERK2 (MAPK3/MAPK1)
→
p90RSK (RPS6KA1)
(modification, activates)
-
KEGG Oocyte meiosis:
MAPK1/MAPK3
→
RPS6KA1/RPS6KA2/RPS6KA3/RPS6KA6
(protein-protein, activation)
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KEGG Long-term potentiation:
MAPK1/MAPK3
→
RPS6KA1/RPS6KA2/RPS6KA3/RPS6KA6
(protein-protein, activation)
-
KEGG Neurotrophin signaling pathway:
MAPK1/MAPK3
→
RPS6KA1/RPS6KA2/RPS6KA3/RPS6KA6
(protein-protein, activation)
-
KEGG Progesterone-mediated oocyte maturation:
MAPK1/MAPK3
→
RPS6KA1/RPS6KA2/RPS6KA3/RPS6KA6
(protein-protein, activation)
-
KEGG MAPK signaling pathway:
MAPK1/MAPK3
→
RPS6KA1/RPS6KA2/RPS6KA3/RPS6KA6
(protein-protein, phosphorylation)
-
NCI Pathway Database FGF signaling pathway:
Erk1-2-active (MAPK3/MAPK1)
→
p90-RSK 1 (RPS6KA1)
(modification, activates)
Newman et al., Am J Physiol Lung Cell Mol Physiol 2004*
Evidence: mutant phenotype, assay
-
Reactome Reaction:
RPS6KA1
→
MAPK3
(reaction)
Ranganathan et al., Arch Biochem Biophys 2006*
-
WikiPathways Insulin Signaling:
MINK1/MAP4K4/MAP3K2/MAPK12/MAP3K5/MAPK10/MAP3K3/MAP4K1/MAPK3/MAP2K7/MAPK13/MAP3K1/MAP4K3/MAP2K6/MAP3K8/MAP3K12/MAP2K4/MAPK7/MAPK14/MAP3K11/MAP3K7/MAPK11/MAPK9/MAPK6/MAP3K13/MAP2K3/MAPK4/MAP4K2/MAP2K5/MAP3K10/MAPK1/MAP2K1/MAP3K6/MAP3K4/MAP3K9/MAP4K5/MAP2K2/MAPK8/MAP3K14
→
RPS6KA4/RPS6KA3/RPS6KA6/RPS6KA5/RPS6KA1/RPS6KA2
(activation)
-
WikiPathways Angiopoietin Like Protein 8 Regulatory Pathway:
MAP2K1/MAP3K7/MAPK14/MAPK1/MAP2K2/MAP3K2/MAP3K6/MAPK8/MAP4K1/MAP3K11/MAP4K3/MAPK10/MAP2K7/MAP3K4/MAP3K1/MAP3K12/MAPK4/MAPK11/MAP4K5/MAPK6/MAP4K4/MAPK3/MAP3K14/MAPK12/MAP2K5/MAP2K4/MAPK13/MAP3K5/MAPK9/MAPK7/MAP3K3/MAP3K9/MAP3K8/MAP2K6/MAP3K13/MAP4K2/MAP2K3/MAP3K10/MINK1
→
RPS6KA5/RPS6KA6/RPS6KA4/RPS6KA1/RPS6KA2/RPS6KA3
(activation)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
MAPK3
—
RPS6KA1
(physical association, affinity chromatography technology)
Roux et al., Mol Cell Biol 2003*
-
IRef Hprd Interaction:
MAPK3
—
RPS6KA1
(in vivo)
Roux et al., Mol Cell Biol 2003*, Smith et al., J Biol Chem 1999*
-
IRef Hprd Interaction:
MAPK3
—
RPS6KA1
(in vitro)
Roux et al., Mol Cell Biol 2003*, Smith et al., J Biol Chem 1999*
-
IRef Innatedb Interaction:
MAPK3
—
RPS6KA1
(unknown, -)
Roux et al., Mol Cell Biol 2003*
-
IRef Ophid Interaction:
MAPK3
—
RPS6KA1
(aggregation, confirmational text mining)
Roux et al., Mol Cell Biol 2003*
-
IRef Ophid Interaction:
MAPK3
—
RPS6KA1
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Butcher et al., Eur J Neurosci 2004
(MAP Kinase Signaling System) :
In vivo pharmacological inhibition of light induced
MAPK pathway activation
blocked RSK-1 phosphorylation, indicating that RSK-1 activity is regulated by the MAPK pathway
Larrea et al., Proc Natl Acad Sci U S A 2009
(MAP Kinase Signaling System) :
Because
RSK1 is also
activated by
MAPK , the increased cell motility and metastatic potential of cancer cells with PI3K and/or MAPK pathway activation may result in part from RSK1 activation, leading to accumulation of p27T198 in the cytoplasm, p27 : RhoA binding, inhibition of RhoA/Rock pathway activation, and loss of actomyosin stability