◀ Back to CREB1
CREB1 — RPS6KA1
Pathways - manually collected, often from reviews:
-
BioCarta melanocyte development and pigmentation pathway:
p90RSK (RPS6KA1)
→
CREB (CREB1)
(modification, activates)
-
NCI Pathway Database VEGFR3 signaling in lymphatic endothelium:
p90S6K (RPS6KA1)
→
CREB1 (CREB1)
(modification, activates)
Mayo et al., J Biol Chem 2001*, Mäkinen et al., EMBO J 2001
Evidence: assay
-
NCI Pathway Database Trk receptor signaling mediated by the MAPK pathway:
p90S6K (RPS6KA1)
→
CREB1 (CREB1)
(modification, activates)
Watson et al., Nat Neurosci 2001*, Xing et al., Mol Cell Biol 1998*
Evidence: mutant phenotype, assay, other species
-
Reactome Reaction:
CREB1
→
RPS6KA1
(reaction)
Harum et al., Neurology 2001*, De Cesare et al., Proc Natl Acad Sci U S A 1998*
-
WikiPathways BDNF-TrkB Signaling:
RPS6KA1
→
CREB1
(activation)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
RPS6KA1
—
CREB1
(physical association, proximity labelling technology)
Choi et al., J Biol Chem 2011*
-
IRef Hprd Interaction:
CREB1
—
RPS6KA1
(in vitro)
Gudi et al., Oncogene 2000*, Hamm et al., J Biol Chem 2002*, Xing et al., Science 1996*, Deak et al., EMBO J 1998, Du et al., J Biol Chem 1998*
-
IRef Intact Interaction:
CREB1
—
RPS6KA1
(phosphorylation reaction, protein kinase assay)
Qi et al., J Biol Chem 2006*
-
STRING interaction:
RPS6KA1
—
CREB1
(interaction, mapped from kegg_pathways)
-
STRING interaction:
CREB1
—
RPS6KA1
(interaction, mapped from kegg_pathways)
Text-mined interactions from Literome
Hu et al., J Biol Chem 2004
:
Nuclear RSK1 kinase activity and
RSK1 activation of
CREB were enhanced by transfected FGFR1 ... In contrast, kinase deleted FGFR1 ( TK- ), which did not bind to RSK1 failed to stimulate nuclear
RSK1 activity or RSK1
activation of
CREB
Neithardt et al., J Cell Physiol 2006
:
Moreover, overexpression of wild-type
RSK-1 resulted in enhanced basal as well as agonist induced phosphorylation of
CREB and BAD, indicating a critical role of RSK-1 in activating cytosolic as well as nuclear proteins
Kim et al., J Cell Biochem 2009
:
We also found that
RSK1 mediated the IL-4 induced phosphorylation of cAMP response element binding protein (
CREB ) and the transcription of MUC5AC
Kim et al., Mol Cells 2011
(MAP Kinase Signaling System...) :
We also found that
RSK1 mediated the PGN induced phosphorylation of cAMP response element binding protein (
CREB ) and the transcription of MUC5AC