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IGF1 — RPS6
Text-mined interactions from Literome
Roberts et al., Biochem Pharmacol 2004
:
First, we confirmed that increased phosphorylation of the
40S ribosomal S6 protein ( a cellular substrate for both p70 ( S6K ) and the 90 kDa ribosomal S6 kinase ) in
response to stimulation of ARVM by
insulin-like growth factor-1 ( 300 ng/mL ; 10 min ) occurs specifically through rapamycin-sensitive activation of p70 ( S6K )
Vary et al., Am J Physiol Regul Integr Comp Physiol 2006
(Sepsis) :
In addition, phosphorylation of eIF4G and
ribosomal protein S6 kinase-1 ( S6K1 ) was also
enhanced by
IGF-I
Jaquish et al., Carcinogenesis 2011
(Pancreatic Neoplasms) :
In pancreatic cancer cells, unlike childhood sarcoma, STAT-3, rather than
RPS6 , is activated in
response to
IGF-1 , in a RON dependent manner