Gene interactions and pathways from curated databases and text-mining

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IGF1 — RPS6

Text-mined interactions from Literome

Roberts et al., Biochem Pharmacol 2004 : First, we confirmed that increased phosphorylation of the 40S ribosomal S6 protein ( a cellular substrate for both p70 ( S6K ) and the 90 kDa ribosomal S6 kinase ) in response to stimulation of ARVM by insulin-like growth factor-1 ( 300 ng/mL ; 10 min ) occurs specifically through rapamycin-sensitive activation of p70 ( S6K )
Vary et al., Am J Physiol Regul Integr Comp Physiol 2006 (Sepsis) : In addition, phosphorylation of eIF4G and ribosomal protein S6 kinase-1 ( S6K1 ) was also enhanced by IGF-I
Jaquish et al., Carcinogenesis 2011 (Pancreatic Neoplasms) : In pancreatic cancer cells, unlike childhood sarcoma, STAT-3, rather than RPS6 , is activated in response to IGF-1 , in a RON dependent manner