Gene interactions and pathways from curated databases and text-mining

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IL12A — RPL17

Text-mined interactions from Literome

Cho et al., Immunol Lett 2009 : PD-1 mediated suppression of IL-12 production in LPS stimulated RAW264.7 cells was mediated by inhibition of Janus N-terminal linked kinase ( JNK ) signaling pathway, and to a lesser extent, phosphatidylinositol 3-kinase (PI3K)/protein kinase B ( Akt ) pathway through the recruitment of SHP-2 to PD-1 cytoplasmic tail
Ma et al., Immunology 2011 (Hepatitis C, Chronic) : To determine whether PD-1 regulates IL-12 production by M/Mf during chronic HCV infection, we examined the expressions of PD-1, its ligand PDL-1, and their relationship with IL-12 production in M/Mf from HCV infected, HCV resolved, and healthy subjects by flow cytometry
Zhang et al., J Immunol 2011 (Hepatitis C, Chronic) : Blocking gC1qR rescued HCV core induced PD-1 upregulation and IL-12 suppression, whereas blocking PD-1 signaling enhanced IL-12 production and decreased the expression of SOCS-1 induced by HCV core ... Conversely, silencing SOCS-1 expression using small interfering RNAs increased IL-12 expression and inhibited PD-1 upregulation