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ROR1 — STAT3
Text-mined interactions from Literome
Papanastasiou et al., Mol Immunol 2010
:
In addition, as shown by qRT-PCR, the mutation abrogates the
STAT3 dependent transcription of the retinoid related orphan receptor gammat (
ROR gammat ) gene, an indispensable transcription factor for the commitment of naive CD4+ T cells to the Th17 lineage
Li et al., PloS one 2010
(Leukemia, Lymphocytic, Chronic, B-Cell) :
Because Stat3 is constitutively activated in CLL and sequence analysis revealed that the ROR1 promoter harbors gamma-interferon activation sequence-like elements typically activated by Stat3, we hypothesized that
Stat3 activates
ROR1
Yang et al., Nat Immunol 2011
:
Whereas
STAT3 induced IL-17 and the transcription factor
ROR?t and inhibited the transcription factor Foxp3, IL-2 inhibited IL-17 independently of Foxp3 and ROR?t
Wang et al., Cell Res 2011
(Diabetes Mellitus, Experimental) :
T-cell vaccination leads to suppression of intrapancreatic Th17 cells through
Stat3 mediated
ROR?t inhibition in autoimmune diabetes
Ma et al., PloS one 2013
:
IL-6 induces the differentiation of Th17 cells from naïve CD4 ( + ) T cells through
STAT3 activation and
ROR?t induction