Gene interactions and pathways from curated databases and text-mining

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CASP5 — ROCK1

Text-mined interactions from Literome

Coleman et al., Nat Cell Biol 2001 : Membrane blebbing during apoptosis results from caspase mediated activation of ROCK I
Sebbagh et al., Nat Cell Biol 2001 : Thus, activation of ROCK I by caspase-3 seems to be responsible for bleb formation in apoptotic cells
Ueda et al., J Biol Chem 2001 : Galpha11 induces caspase mediated proteolytic activation of Rho associated kinase, ROCK-I , in HeLa cells ... Galpha11 induces caspase mediated proteolytic activation of Rho associated kinase, ROCK-I , in HeLa cells
Ueda et al., Exp Cell Res 2004 : We have previously reported that expression of the constitutively active mutant of Galpha11 or stimulation of m1 muscarinic acetylcholine receptor induced proteolytic activation of Rho associated kinase (ROCK-I) by caspase and apoptosis in HeLa cells
Croft et al., J Cell Biol 2005 : Membrane blebbing during the apoptotic execution phase results from caspase mediated cleavage and activation of ROCK I
Söderström et al., J Cell Sci 2005 : CD95 activated RhoA exclusively in the type II cell, whereas ROCK activation was caspase dependent in the type I cell
Chang et al., Proc Natl Acad Sci U S A 2006 (Disease Models, Animal...) : ROCK-1 dependent caspase-3 activation was coupled with the activation of PTEN and the subsequent inhibition of protein kinase B ( Akt ) activity, all of which was attenuated by siRNA directed against ROCK-1 expression
Koyanagi et al., J Neurosci Res 2008 : Membrane blebbing, which is an early morphological sign of apoptosis ; cleavage of caspase-3 ; and release of cytochrome c from the mitochondria are also reduced by ROCK inhibition
Gabet et al., Cell Death Differ 2011 : Therefore, in this differentiation system, final maturation occurs independently of SCF signaling through caspase induced ROCK-1 kinase activation
Iwasaki et al., Mol Biol Cell 2013 : During apoptosis, caspase-3 activated Rho associated protein kinase I triggers hyperphosphorylation of myosin II, leading to membrane blebbing