Gene interactions and pathways from curated databases and text-mining

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CASP5 — RIPK3

Text-mined interactions from Literome

Gentle et al., J Biol Chem 2011 : After receptor ligation, RIPK1 not only modulates activation of both canonical and NIK dependent NF-?B, but also regulates caspase-8 activation and cell death
Duprez et al., Immunity 2011 (Cecal Diseases...) : An additional switch decides, depending on the cellular context, between caspase dependent apoptosis and RIP kinase ( RIPK ) -mediated necrosis, also termed necroptosis
Dillon et al., Cell reports 2012 (Necrosis) : This can be explained by the convergence of two cell processes : the enzymatic activity of the FADD-caspase-8-cFLIPL complex blocks RIPK3 dependent signaling ( including necrosis ), whereas cFLIPL blocks RIPK3 independent apoptosis promoted by the FADD-caspase-8 complex
Kaczmarek et al., Immunity 2013 (Bacterial Infections...) : Regulated necrosis, termed necroptosis, is negatively regulated by caspase-8 and is dependent on the kinase activity of RIPK1 and RIPK3
Dondelinger et al., Cell Death Differ 2013 : In both TNF induced RIPK1 kinase dependent apoptotic models, we found that RIPK3 contributes to full caspase-8 activation independently of its kinase activity or intact RHIM domain