Gene interactions and pathways from curated databases and text-mining

◀ Back to CASP7

CASP7 — RIPK1

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Martinet et al., Autophagy 2006 (Atherosclerosis) : This finding suggests that caspase inhibition activates RIP1 which in turn initiates autophagy, although other explanations should be taken into account
Wang et al., Cell 2008 : RIPK1 is critical for caspase-8 activation induced by Smac mimetic but dispensable for that triggered by cycloheximide
Morgan et al., J Immunol 2009 : Membrane bound Fas ligand requires RIP1 for efficient activation of caspase-8 within the death inducing signaling complex
Gentle et al., J Biol Chem 2011 : After receptor ligation, RIPK1 not only modulates activation of both canonical and NIK dependent NF-?B, but also regulates caspase-8 activation and cell death ... After receptor ligation, RIPK1 not only modulates activation of both canonical and NIK dependent NF-?B, but also regulates caspase-8 activation and cell death
Löder et al., Leukemia 2012 (Precursor Cell Lymphoblastic Leukemia-Lymphoma) : Similarly, inhibition of RIP1 kinase activity by Necrostatin-1 or blockage of TNFa by Enbrel inhibits IAP inhibitor- and AraC triggered interaction of RIP1, FADD and caspase-8 and apoptosis
Duprez et al., Immunity 2011 (Cecal Diseases...) : An additional switch decides, depending on the cellular context, between caspase dependent apoptosis and RIP kinase ( RIPK ) -mediated necrosis, also termed necroptosis
Basit et al., J Biol Chem 2012 (Rhabdomyosarcoma) : Importantly, knockdown of RIP1 by RNA interference prevented the formation of the RIP1·FADD·caspase-8 complex and inhibited subsequent activation of caspase-8 , -9, and -3 ; loss of mitochondrial membrane potential ; and apoptosis upon treatment with IAP inhibitor and lexatumumab
Kaczmarek et al., Immunity 2013 (Bacterial Infections...) : Regulated necrosis, termed necroptosis, is negatively regulated by caspase-8 and is dependent on the kinase activity of RIPK1 and RIPK3