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MAPK6 — RHOA

Text-mined interactions from Literome

Vial et al., Cancer Cell 2003 (Colonic Neoplasms...) : ERK-MAPK signaling coordinately regulates activity of Rac1 and RhoA for tumor cell motility
Calleros et al., Apoptosis 2006 : Finally, overexpression of the dominant negative N19RhoA inhibited p38 MAPK phosphorylation and apoptosis induced by low cholesterol levels
Horowitz et al., Am J Physiol Gastrointest Liver Physiol 2007 (Crohn Disease...) : The RhoA inhibitor C3 exoenzyme and the ROCK inhibitor Y-27632 both attenuated TNF-alpha/lipopolysaccharide induced MAPK activation and blocked AR expression in HIMEC
Yano et al., Circ Res 2007 (Inflammation) : However, DN-RhoA and DN-Cdc42 activated p38 MAPK , but not ERK1/2
Zeidan et al., Cardiovasc Res 2008 (Cardiomegaly) : Leptin induced cardiomyocyte hypertrophy involves selective caveolae and RhoA/ROCK dependent p38 MAPK translocation to nuclei
Spindler et al., J Immunol 2010 (Disease Models, Animal...) : Several intracellular signaling pathways, such as p38MAPK activation and RhoA inhibition , have been demonstrated to be altered following autoantibody binding and to be causally involved in loss of keratinocyte cohesion
Shatanawi et al., Am J Physiol Cell Physiol 2011 : ANG II also elevates active RhoA levels and induces phosphorylation of p38 MAPK
Moey et al., J Pharmacol Exp Ther 2011 (Cardiomegaly) : These results demonstrate a potent inhibitory effect of ginseng against leptin induced cardiac hypertrophy, an effect associated with prevention of p115RhoGEF-RhoA/ROCK dependent p38 MAPK activation